Enhanced antitumor efficacy of gemcitabine-loaded temperature-sensitive liposome by hyperthermia in tumor-bearing mice
DC Field | Value | Language |
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dc.contributor.author | Lim, Sun-Kyung | - |
dc.contributor.author | Shin, Dae Hwan | - |
dc.contributor.author | Choi, Mi-Hee | - |
dc.contributor.author | Kim, Jin-Seok | - |
dc.date.available | 2021-02-22T12:00:44Z | - |
dc.date.issued | 2014-04 | - |
dc.identifier.issn | 0363-9045 | - |
dc.identifier.issn | 1520-5762 | - |
dc.identifier.uri | https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/10938 | - |
dc.description.abstract | Introduction: Gemcitabine-loaded TSL (Gem-TSL) was used in combination with hyperthermia (HT) to treat the colon adenocarcinoma-bearing BALB/c mice for improved anticancer effect following intravenous administration. Methods: A new temperature-sensitive liposome (TSL), composed of DPPC: DMPC: DSPC (4: 1: 1 molar ratio) releasing the encapsulated gemcitabine (Gem) at 41 degrees C, was developed and evaluated for enhanced antitumor efficacy both in vitro and in vivo. Results: Drug release from the TSL was sharply increased at 41 degrees C and in vitro cytotoxicity of Gem-TSL in colon adenocarcinoma cells (CT-26) was 10 times higher than the free drug (IC50 = 0.3 mu M versus 3 mu M). Apoptosis seemed to be the main mechanism of cell death as the treatment of the cells with Gem-TSL increased the caspse-3/7 activity by 1.5-fold and also caused the fragmentation of chromatin DNA. Gem-TSL suppressed the tumor growth in CT-26-bearing BALB/c mice more stronger than the free gemcitabine after intravenous administration. Moreover, this in vivo antitumor efficacy of Gem-TSL was further increased when HT was added. Discussion: This study suggests that this new TSL-Gem formulation could serve as a new chemotherapy modality together with HT. | - |
dc.format.extent | 7 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | TAYLOR & FRANCIS LTD | - |
dc.title | Enhanced antitumor efficacy of gemcitabine-loaded temperature-sensitive liposome by hyperthermia in tumor-bearing mice | - |
dc.type | Article | - |
dc.publisher.location | 영국 | - |
dc.identifier.doi | 10.3109/03639045.2013.768631 | - |
dc.identifier.scopusid | 2-s2.0-84896697280 | - |
dc.identifier.wosid | 000332036000005 | - |
dc.identifier.bibliographicCitation | DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, v.40, no.4, pp 470 - 476 | - |
dc.citation.title | DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY | - |
dc.citation.volume | 40 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 470 | - |
dc.citation.endPage | 476 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.subject.keywordPlus | CIRCULATING THERMOSENSITIVE LIPOSOMES | - |
dc.subject.keywordPlus | DELIVERY | - |
dc.subject.keywordPlus | DOXORUBICIN | - |
dc.subject.keywordPlus | RELEASE | - |
dc.subject.keywordAuthor | Colon cancer therapy | - |
dc.subject.keywordAuthor | gemcitabine | - |
dc.subject.keywordAuthor | hyperthermia | - |
dc.subject.keywordAuthor | temperature-sensitive liposomes | - |
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