In Vivo Expression of EphrinA5-Fc in Mice Results in Cephalic Neural Crest Agenesis and Craniofacial Abnormalities
DC Field | Value | Language |
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dc.contributor.author | Noh, Hyuna | - |
dc.contributor.author | Park, Eunjeong | - |
dc.contributor.author | Park, Soochul | - |
dc.date.available | 2021-02-22T12:01:25Z | - |
dc.date.issued | 2014-01 | - |
dc.identifier.issn | 1016-8478 | - |
dc.identifier.issn | 0219-1032 | - |
dc.identifier.uri | https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/11000 | - |
dc.description.abstract | Eph receptors and their ligands ephrins have been implicated in guiding the directed migration of neural crest cells (NCCs). In this study, we found that Wnt1-Cre-mediated expression of ephrinA5-Fc along the dorsal midline of the dien-and mesencephalon resulted in severe craniofacial malformation of mouse embryo. Interestingly, expression of cephalic NCC markers decreased significantly in the frontonasal process and branchial arches 1 and 2, which are target areas for the migratory cephalic NCCs originating in the dien-and mesencephalon. In addition, these craniofacial tissues were much smaller in mutant embryos expressing ephrinA5-Fc. Importantly, EphA7-positive cephalic NCCs were absent along the dorsal dien-and mesencephalon of mutant embryos expressing ephrinA5-Fc, suggesting that the generation of cephalic NCCs is disrupted due to ephrinA5-Fc expression. NCC explant experiments suggested that ephrinA5-Fc perturbed survival of cephalic NCC precursors in the dorsal midline tissue rather than affecting their migratory capacity, which was consistent with our previous report that expression of ephrinA5-Fc in the dorsal midline is responsible for severe neuroepithelial cell apoptotic death. Taken together, our findings strongly suggest that expression of ephrinA5-Fc decreases a population of cephalic NCC precursors in the dorsal midline of the dien-and mesencephalon, thereby disrupting craniofacial development in the mouse embryos. | - |
dc.format.extent | 7 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | KOREAN SOC MOLECULAR & CELLULAR BIOLOGY | - |
dc.title | In Vivo Expression of EphrinA5-Fc in Mice Results in Cephalic Neural Crest Agenesis and Craniofacial Abnormalities | - |
dc.type | Article | - |
dc.publisher.location | 대한민국 | - |
dc.identifier.doi | 10.14348/molcells.2014.2279 | - |
dc.identifier.scopusid | 2-s2.0-84901409968 | - |
dc.identifier.wosid | 000342559100009 | - |
dc.identifier.bibliographicCitation | MOLECULES AND CELLS, v.37, no.1, pp 59 - 65 | - |
dc.citation.title | MOLECULES AND CELLS | - |
dc.citation.volume | 37 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 59 | - |
dc.citation.endPage | 65 | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART001847553 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.subject.keywordPlus | TRANSCRIPTION FACTOR AP-2 | - |
dc.subject.keywordPlus | BETA-CATENIN | - |
dc.subject.keywordPlus | INT-1 PROTOONCOGENE | - |
dc.subject.keywordPlus | SIGNALING PATHWAY | - |
dc.subject.keywordPlus | BRAIN-DEVELOPMENT | - |
dc.subject.keywordPlus | MOUSE DEVELOPMENT | - |
dc.subject.keywordPlus | EPHA RECEPTORS | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | APOPTOSIS | - |
dc.subject.keywordPlus | MIGRATION | - |
dc.subject.keywordAuthor | cephalic neural crest | - |
dc.subject.keywordAuthor | early brain development | - |
dc.subject.keywordAuthor | EphA | - |
dc.subject.keywordAuthor | ephrin-A | - |
dc.identifier.url | http://www.molcells.org/journal/view.html?doi=10.14348/molcells.2014.2279 | - |
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