Cyanidin-3-O-Sambubioside from Acanthopanax sessiliflorus Fruit Inhibits Metastasis by Downregulating MMP-9 in Breast Cancer Cells MDA-MB-231
DC Field | Value | Language |
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dc.contributor.author | Lee, Sang-Jin | - |
dc.contributor.author | Hong, Sungyoul | - |
dc.contributor.author | Yoo, Sang-Ho | - |
dc.contributor.author | Kim, Gye-Won | - |
dc.date.available | 2021-02-22T12:03:19Z | - |
dc.date.issued | 2013-11 | - |
dc.identifier.issn | 0032-0943 | - |
dc.identifier.issn | 1439-0221 | - |
dc.identifier.uri | https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/11196 | - |
dc.description.abstract | Anthocyanins play an important role in physiological functions related to human health. This study aimed to investigate the inhibitory effect of cyanidin-3-O-sambubioside isolated from Acanthopanax sessiliflorus fruit on cancer cell metastasis. The inhibitory effect of cyanidin-3-O-sambubioside on angiogenesis was assessed by chorioallantoic membrane and tube formation assays. Cyanidin-3-O-sambubioside interrupted the formation of neovasculature and tube-like structures in a dose-dependent manner. It inhibited the wound healing migration and invasion of MDA-MB-231 cells through reconstituted extracellular matrix (Matrigel). Gelatin zymography revealed that cyanidin-3-O-sambubioside significantly decreased the secretion of matrix metalloproteinase-9 and inhibited matrix metalloproteinase-9 expression. In additional, cyanidin-3-O-sambubioside exerted an inhibitory effect on Akt phosphorylation. These results suggest that cyanidin-3-O-sambubioside inhibits metastasis processes, such as angiogenesis and invasion, in breast cancer cells through regulation of matrix metalloproteinase-9 activity. | - |
dc.format.extent | 5 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | GEORG THIEME VERLAG KG | - |
dc.title | Cyanidin-3-O-Sambubioside from Acanthopanax sessiliflorus Fruit Inhibits Metastasis by Downregulating MMP-9 in Breast Cancer Cells MDA-MB-231 | - |
dc.type | Article | - |
dc.publisher.location | 독일 | - |
dc.identifier.doi | 10.1055/s-0033-1350954 | - |
dc.identifier.scopusid | 2-s2.0-84889560620 | - |
dc.identifier.wosid | 000327472000007 | - |
dc.identifier.bibliographicCitation | PLANTA MEDICA, v.79, no.17, pp 1636 - 1640 | - |
dc.citation.title | PLANTA MEDICA | - |
dc.citation.volume | 79 | - |
dc.citation.number | 17 | - |
dc.citation.startPage | 1636 | - |
dc.citation.endPage | 1640 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Plant Sciences | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalResearchArea | Integrative & Complementary Medicine | - |
dc.relation.journalWebOfScienceCategory | Plant Sciences | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
dc.relation.journalWebOfScienceCategory | Integrative & Complementary Medicine | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.subject.keywordPlus | MATRIX METALLOPROTEINASES | - |
dc.subject.keywordPlus | ANTHOCYANINS | - |
dc.subject.keywordPlus | JUICE | - |
dc.subject.keywordAuthor | angiogenesis | - |
dc.subject.keywordAuthor | cancer metastasis | - |
dc.subject.keywordAuthor | cyanidin-3-O-sambubioside | - |
dc.subject.keywordAuthor | fruit of Acanthopanax sessiliflorus | - |
dc.subject.keywordAuthor | Araliaceae | - |
dc.subject.keywordAuthor | invasion | - |
dc.subject.keywordAuthor | MMP-9 | - |
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