Thymosin beta-4 promotes mesenchymal stem cell proliferation via an interleukin-8-dependent mechanism
DC Field | Value | Language |
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dc.contributor.author | Jeon, Byung-Joon | - |
dc.contributor.author | Yang, Yoolhee | - |
dc.contributor.author | Shim, Su Kyung | - |
dc.contributor.author | Yang, Heung-Mo | - |
dc.contributor.author | Cho, Daeho | - |
dc.contributor.author | Bang, Sa Ik | - |
dc.date.available | 2021-02-22T12:03:20Z | - |
dc.date.issued | 2013-10 | - |
dc.identifier.issn | 0014-4827 | - |
dc.identifier.issn | 1090-2422 | - |
dc.identifier.uri | https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/11198 | - |
dc.description.abstract | Mesenchymal stem cells (MSCs) hold great promise for the field of tissue regeneration. Because only a limited number of MSCs can be obtained from each donor site, it is important to establish standard methods for MSC expansion using growth and trophic factors. Thymosin beta 4 (T beta 4) is a novel trophic factor that has antimicrobial effects and the potential to promote tissue repair. T beta 4 is a ubiquitous, naturally-occurring peptide in the wound bed. Therefore, the relationship between T beta 4 and MSCs, especially adjacent adipose tissue-derived stem cells (ASCs), merits consideration. Exogenous T beta 4 treatment enhanced the proliferation of human ASCs, resulting in prominent nuclear localization of PCNA immunoreactivity. In addition, exogenous T beta 4 also increased IL-8 secretion and blocking of IL-8 with neutralizing antibodies decreased T beta 4-induced ASC proliferation, suggesting that IL-8 is a critical mediator of T beta 4-enhanced proliferation. Moreover, T beta 4 activated phosphorylation of ERK1/2 and increased the nuclear translocation of NF-kappa B. These observation provide that T beta 4 promotes the expansion of human ASCs via an IL-8-dependent mechanism that involves the ERK and NF-kappa B pathways. Therefore, T beta 4 could be used as a tool for MSC expansion in cell therapeutics. (C) 2013 Published by Elsevier Inc. | - |
dc.format.extent | 9 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | ELSEVIER INC | - |
dc.title | Thymosin beta-4 promotes mesenchymal stem cell proliferation via an interleukin-8-dependent mechanism | - |
dc.type | Article | - |
dc.publisher.location | 미국 | - |
dc.identifier.doi | 10.1016/j.yexcr.2013.04.014 | - |
dc.identifier.scopusid | 2-s2.0-84885373263 | - |
dc.identifier.wosid | 000326006100003 | - |
dc.identifier.bibliographicCitation | EXPERIMENTAL CELL RESEARCH, v.319, no.17, pp 2526 - 2534 | - |
dc.citation.title | EXPERIMENTAL CELL RESEARCH | - |
dc.citation.volume | 319 | - |
dc.citation.number | 17 | - |
dc.citation.startPage | 2526 | - |
dc.citation.endPage | 2534 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Oncology | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.subject.keywordPlus | NF-KAPPA-B | - |
dc.subject.keywordPlus | ADIPOSE-TISSUE | - |
dc.subject.keywordPlus | DIFFERENTIATION | - |
dc.subject.keywordPlus | IL-8 | - |
dc.subject.keywordPlus | MIGRATION | - |
dc.subject.keywordPlus | CORNEAL | - |
dc.subject.keywordPlus | KINASE | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | APOPTOSIS | - |
dc.subject.keywordPlus | SURVIVAL | - |
dc.subject.keywordAuthor | Mesenchymal stem cells | - |
dc.subject.keywordAuthor | Thymosin beta 4 | - |
dc.subject.keywordAuthor | Cell proliferation | - |
dc.subject.keywordAuthor | Interleukin-8 | - |
dc.subject.keywordAuthor | ERK pathway, NF-kappa B | - |
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