Autophagy induction promotes renal cyst growth in polycystic kidney disease
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Eun Ji | - |
dc.contributor.author | Ko, Je Yeong | - |
dc.contributor.author | Oh, Sumin | - |
dc.contributor.author | Jun, Jaehee | - |
dc.contributor.author | Mun, Hyowon | - |
dc.contributor.author | Lim, Chae Ji | - |
dc.contributor.author | Seo, Seungwoon | - |
dc.contributor.author | Ko, Hyuk Wan | - |
dc.contributor.author | Kim, Hyunho | - |
dc.contributor.author | Oh, Yun Kyu | - |
dc.contributor.author | Ahn, Curie | - |
dc.contributor.author | Kang, Minyong | - |
dc.contributor.author | 김민정 | - |
dc.contributor.author | 유경현 | - |
dc.contributor.author | Oh, Goo Taeg | - |
dc.contributor.author | 박종훈 | - |
dc.date.available | 2021-02-22T05:21:44Z | - |
dc.date.issued | 2020-10 | - |
dc.identifier.issn | 2352-3964 | - |
dc.identifier.issn | 2352-3964 | - |
dc.identifier.uri | https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/1141 | - |
dc.description.abstract | Background: Polycystic kidney disease (PKD) involves renal cysts arising from proliferating tubular cells. Autophagy has been recently suggested as a potential therapeutic target in PKD, and mammalian target of rapamycin (mTOR) is a key negative regulator of autophagy. However, the effect of autophagy regulation on cystogenesis has not been elucidated in PKD mice. Methods: Clinical validation was performed using GEO datasets and autosomal dominant polycystic kidney disease (ADPKD) patient samples. Newly established PKD and LC3 transgenic mice were used for in vivo verifications, and additional tests were performed in vitro and in vivo using multiple autophagy drugs. Findings: Neither autophagy stimulation nor LC3 overexpression alleviated PKD. Furthermore, we observed the inhibitory effect of an autophagy inhibitor on cysts, indicating its possible therapeutic use in a specific group of patients with ADPKD. Interpretation: Our findings provide a novel insight into the pathogenesis related to autophagy in PKD, suggesting that drugs related to autophagy regulation should be considered with caution for treating PKD. Funding Sources: This work was supported by grants from the Bio & Medical Technology Development Program; the Collaborative Genome Program for Fostering New Post-Genome Industry of the NRF; the Basic Science Program. (c) 2020 The Authors. Published by Elsevier B.V. | - |
dc.format.extent | 12 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | ELSEVIER | - |
dc.title | Autophagy induction promotes renal cyst growth in polycystic kidney disease | - |
dc.type | Article | - |
dc.publisher.location | 네델란드 | - |
dc.identifier.doi | 10.1016/j.ebiom.2020.102986 | - |
dc.identifier.scopusid | 2-s2.0-85090893628 | - |
dc.identifier.wosid | 000580572100011 | - |
dc.identifier.bibliographicCitation | EBIOMEDICINE, v.60, pp 1 - 12 | - |
dc.citation.title | EBIOMEDICINE | - |
dc.citation.volume | 60 | - |
dc.citation.startPage | 1 | - |
dc.citation.endPage | 12 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | General & Internal Medicine | - |
dc.relation.journalResearchArea | Research & Experimental Medicine | - |
dc.relation.journalWebOfScienceCategory | Medicine, General & Internal | - |
dc.relation.journalWebOfScienceCategory | Medicine, Research & Experimental | - |
dc.subject.keywordPlus | GENE-EXPRESSION | - |
dc.subject.keywordPlus | RAT MODEL | - |
dc.subject.keywordPlus | PROGRESSION | - |
dc.subject.keywordPlus | SIROLIMUS | - |
dc.subject.keywordPlus | MECHANOSENSATION | - |
dc.subject.keywordPlus | PROLIFERATION | - |
dc.subject.keywordPlus | PATHOGENESIS | - |
dc.subject.keywordPlus | EVEROLIMUS | - |
dc.subject.keywordPlus | SYSTEMS | - |
dc.subject.keywordPlus | MTOR | - |
dc.subject.keywordAuthor | Polycystic kidney | - |
dc.subject.keywordAuthor | PKD | - |
dc.subject.keywordAuthor | Autophagy | - |
dc.subject.keywordAuthor | Ift46 | - |
dc.identifier.url | https://www.thelancet.com/journals/ebiom/article/PIIS2352-3964(20)30362-5/fulltext | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
Sookmyung Women's University. Cheongpa-ro 47-gil 100 (Cheongpa-dong 2ga), Yongsan-gu, Seoul, 04310, Korea02-710-9127
Copyright©Sookmyung Women's University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.