Quercetin acts as an antioxidant and downregulates CYP1A1 and CYP1B1 against DMBA-induced oxidative stress in mice
DC Field | Value | Language |
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dc.contributor.author | Choi, Eun Jeong | - |
dc.contributor.author | Kim, Taehee | - |
dc.contributor.author | Kim, Gun-Hee | - |
dc.date.available | 2021-02-22T12:46:10Z | - |
dc.date.issued | 2012-07 | - |
dc.identifier.issn | 1021-335X | - |
dc.identifier.issn | 1791-2431 | - |
dc.identifier.uri | https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/11878 | - |
dc.description.abstract | We investigated the effects of quercetin on 7,12-dimethylbenz(a)anthracene (DMBA)-induced oxidative stress and the expression of CYP1A1 and CYP1B1 in mice. Quercetin was administered orally to mice at 100 or 250 mg/kg BW for 18 days, after which DMBA (34 mg/kg BW) was administered intragastrically twice. Quercetin showed side effects such as increased aspartate aminotransferase (AST) and alanine aminotransferase (ALT) in DMBA-untreated mice. Also, quercetin induced AST and ALT in DMBA-treated, although this was not significantly different from levels in DMBA-treated controls. The thiobarbituric acid reactive substances (TBARS) value showed a tendency to decrease following quercetin treatment; these decreases were significantly greater in the DMBA-treated compared to the untreated groups. Also, catalase and superoxide dismutase (SOD) activities as well as their mRNA expression were increased by quercetin; this increase was more pronounced in DMBA-treated compared to untreated mice. DMBA induced CYP1 activity as well as expression of CYP1A1 and CYP1B1. Each of these effects was significantly reduced by quercetin; however, this reduction was observed for CYP1A1 at only the higher dose and for CYP1B1 at both doses. These data suggest that quercetin shows antioxidant activity against DMBA-induced oxidative stress. Moreover, its regulation of CYP1A1 and CYP1B1 suggests the potential of quercetin as an anticancer supplement. | - |
dc.format.extent | 6 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | SPANDIDOS PUBL LTD | - |
dc.title | Quercetin acts as an antioxidant and downregulates CYP1A1 and CYP1B1 against DMBA-induced oxidative stress in mice | - |
dc.type | Article | - |
dc.publisher.location | 그리이스 | - |
dc.identifier.doi | 10.3892/or.2012.1753 | - |
dc.identifier.scopusid | 2-s2.0-84861536632 | - |
dc.identifier.wosid | 000304638900041 | - |
dc.identifier.bibliographicCitation | ONCOLOGY REPORTS, v.28, no.1, pp 291 - 296 | - |
dc.citation.title | ONCOLOGY REPORTS | - |
dc.citation.volume | 28 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 291 | - |
dc.citation.endPage | 296 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Oncology | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.subject.keywordPlus | BUCCAL POUCH CARCINOGENESIS | - |
dc.subject.keywordPlus | LOW-DENSITY-LIPOPROTEIN | - |
dc.subject.keywordPlus | BLACK TEA POLYPHENOLS | - |
dc.subject.keywordPlus | DNA ADDUCT FORMATION | - |
dc.subject.keywordPlus | BREAST-CANCER | - |
dc.subject.keywordPlus | METABOLIC-ACTIVATION | - |
dc.subject.keywordPlus | DIETARY FLAVONOIDS | - |
dc.subject.keywordPlus | HEPG2 CELLS | - |
dc.subject.keywordPlus | A549 CELLS | - |
dc.subject.keywordPlus | RATS | - |
dc.subject.keywordAuthor | antioxidant | - |
dc.subject.keywordAuthor | aryl hydrocarbon receptor | - |
dc.subject.keywordAuthor | CYP1A1 | - |
dc.subject.keywordAuthor | CYP1B1 | - |
dc.subject.keywordAuthor | quercetin | - |
dc.subject.keywordAuthor | mice | - |
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