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Design and synthesis of carbamate and thiocarbamate derivatives and their inhibitory activities of NO production in LPS activated macrophages
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| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Jin, Guo Hua | - |
| dc.contributor.author | Lee, Hwa Jin | - |
| dc.contributor.author | Gim, Hyo Jin | - |
| dc.contributor.author | Ryu, Jae-Ha | - |
| dc.contributor.author | Jeon, Raok | - |
| dc.date.available | 2021-02-22T12:46:27Z | - |
| dc.date.issued | 2012-05-01 | - |
| dc.identifier.issn | 0960-894X | - |
| dc.identifier.issn | 1464-3405 | - |
| dc.identifier.uri | https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/11909 | - |
| dc.description.abstract | Series of carbamate and thiocarbamate derivatives were designed and synthesized and their inhibitory activities of NO production in lipopolysaccharide-activated macrophages were evaluated. Several thoicarbamate derivatives revealed promising inhibitory activity. The structure-activity relationship study of these compounds is also reported. Among these compounds, compound 12b was the most potent with 6.5 mu M of IC50. They inhibited NO production through the suppression of iNOS protein and mRNA expression and nuclear translocation of p65. (C) 2012 Elsevier Ltd. All rights reserved. | - |
| dc.format.extent | 4 | - |
| dc.language | 영어 | - |
| dc.language.iso | ENG | - |
| dc.publisher | PERGAMON-ELSEVIER SCIENCE LTD | - |
| dc.title | Design and synthesis of carbamate and thiocarbamate derivatives and their inhibitory activities of NO production in LPS activated macrophages | - |
| dc.type | Article | - |
| dc.publisher.location | 영국 | - |
| dc.identifier.doi | 10.1016/j.bmcl.2012.03.010 | - |
| dc.identifier.scopusid | 2-s2.0-84859831913 | - |
| dc.identifier.wosid | 000302964300053 | - |
| dc.identifier.bibliographicCitation | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v.22, no.9, pp 3301 - 3304 | - |
| dc.citation.title | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | - |
| dc.citation.volume | 22 | - |
| dc.citation.number | 9 | - |
| dc.citation.startPage | 3301 | - |
| dc.citation.endPage | 3304 | - |
| dc.type.docType | Article | - |
| dc.description.isOpenAccess | N | - |
| dc.description.journalRegisteredClass | sci | - |
| dc.description.journalRegisteredClass | scie | - |
| dc.description.journalRegisteredClass | scopus | - |
| dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
| dc.relation.journalResearchArea | Chemistry | - |
| dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
| dc.relation.journalWebOfScienceCategory | Chemistry, Organic | - |
| dc.subject.keywordPlus | NITRIC-OXIDE SYNTHASE | - |
| dc.subject.keywordAuthor | Carbamate | - |
| dc.subject.keywordAuthor | Thiocarbamate | - |
| dc.subject.keywordAuthor | Nitric oxide | - |
| dc.subject.keywordAuthor | iNOS | - |
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Collections - 약학대학 > 약학부 > 1. Journal Articles
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