R848, a toll-like receptor 7 agonist, inhibits osteoclast differentiation but not survival or bone-resorbing function of mature osteoclasts
DC Field | Value | Language |
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dc.contributor.author | Miyamoto, Arei | - |
dc.contributor.author | Takami, Masamichi | - |
dc.contributor.author | Matsumoto, Akifumi | - |
dc.contributor.author | Mochizuki, Ayako | - |
dc.contributor.author | Yamada, Takako | - |
dc.contributor.author | Tachi, Keita | - |
dc.contributor.author | Shibuya, Isao | - |
dc.contributor.author | Nakamachi, Tomoya | - |
dc.contributor.author | Shioda, Seiji | - |
dc.contributor.author | Baba, Kazuyoshi | - |
dc.contributor.author | Inoue, Tomio | - |
dc.contributor.author | Miyamoto, Yoichi | - |
dc.contributor.author | Yim, Mijung | - |
dc.contributor.author | Kamijo, Ryutaro | - |
dc.date.available | 2021-02-22T12:46:37Z | - |
dc.date.issued | 2012-05 | - |
dc.identifier.issn | 0920-9069 | - |
dc.identifier.issn | 1573-0778 | - |
dc.identifier.uri | https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/11924 | - |
dc.description.abstract | R848, also known as resiquimod, acts as a ligand for toll-like receptor 7 (TLR7) and activates immune cells. In this study, we examined the effects of R848 on differentiation, survival, and bone-resorbing function of osteoclasts. R848 inhibited osteoclast differentiation of mouse bone marrow-derived macrophages (BMMs) and human peripheral blood-derived monocytes induced by receptor activator of NF-kappa B ligand in a dose-dependent manner. In addition, it inhibited mouse osteoclast differentiation induced in cocultures of bone marrow cells and osteoblasts in the presence of dihydroxyvitamin D-3 [1,25(OH)(2)D-3]. However, R848 did not affect the survival or bone-resorbing activity of mouse mature osteoclasts. R848 also upregulated the mRNA expression levels of interleukin (IL)-6, IL-12, interferon (IFN)-gamma, and inducible nitric oxide synthase in mouse BMMs expressing TLR7. IFN-beta was consistently expressed in the BMMs and addition of neutralizing antibodies against IFN-beta to the cultures partially recovered osteoclast differentiation inhibited by R848. These results suggest that R848 targets osteoclast precursors and inhibits their differentiation into osteoclasts via TLR7. | - |
dc.format.extent | 9 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | SPRINGER | - |
dc.title | R848, a toll-like receptor 7 agonist, inhibits osteoclast differentiation but not survival or bone-resorbing function of mature osteoclasts | - |
dc.type | Article | - |
dc.publisher.location | 네델란드 | - |
dc.identifier.doi | 10.1007/s10616-012-9442-5 | - |
dc.identifier.scopusid | 2-s2.0-84863723106 | - |
dc.identifier.wosid | 000305834700012 | - |
dc.identifier.bibliographicCitation | CYTOTECHNOLOGY, v.64, no.3, pp 331 - 339 | - |
dc.citation.title | CYTOTECHNOLOGY | - |
dc.citation.volume | 64 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 331 | - |
dc.citation.endPage | 339 | - |
dc.type.docType | Article; Proceedings Paper | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biotechnology & Applied Microbiology | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Biotechnology & Applied Microbiology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.subject.keywordPlus | NF-KAPPA-B | - |
dc.subject.keywordPlus | PATTERN-RECOGNITION RECEPTORS | - |
dc.subject.keywordPlus | OSTEOBLASTIC CELLS | - |
dc.subject.keywordPlus | INTERFERON-BETA | - |
dc.subject.keywordPlus | INNATE IMMUNITY | - |
dc.subject.keywordPlus | RANKL | - |
dc.subject.keywordPlus | STIMULATION | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | RESORPTION | - |
dc.subject.keywordPlus | LIGAND | - |
dc.subject.keywordAuthor | R848 | - |
dc.subject.keywordAuthor | Resiquimod | - |
dc.subject.keywordAuthor | Osteoclasts | - |
dc.subject.keywordAuthor | Toll-like receptor | - |
dc.subject.keywordAuthor | Cellular differentiation | - |
dc.subject.keywordAuthor | Bone | - |
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