Enhancement of anti-inflammatory and antinociceptive actions of red ginseng extract by fermentation
DC Field | Value | Language |
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dc.contributor.author | Jung H.-J. | - |
dc.contributor.author | Choi H. | - |
dc.contributor.author | Lim H.-W. | - |
dc.contributor.author | Shin D. | - |
dc.contributor.author | Kim H. | - |
dc.contributor.author | Kwon B. | - |
dc.contributor.author | Lee J.E. | - |
dc.contributor.author | Park E.-H. | - |
dc.contributor.author | Lim C.-J. | - |
dc.date.available | 2021-02-22T13:03:28Z | - |
dc.date.issued | 2012-05 | - |
dc.identifier.issn | 0022-3573 | - |
dc.identifier.issn | 2042-7158 | - |
dc.identifier.uri | https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/12383 | - |
dc.description.abstract | Objectives This work aimed to compare some pharmacological properties of red ginseng extract (RG) and fermented red ginseng extract (FRG). Methods Antinociceptive activity was analysed using the acetic acid-induced abdominal constriction response. Anti-inflammatory activity was evaluated using acetic acid-induced vascular permeability and carrageenan-induced inflammation in the air pouch, and analysed through the measurement of nitrite content in the lipopolysaccharide (LPS)-stimulated macrophage cells. Anti-angiogenic activity was determined using the chick chorioallantoic membrane assay. Key findings In-vivo anti-inflammatory activity of FRG was stronger than that of RG in two animal models, vascular permeability and air-pouch models. In the vascular permeability model, the doses of RG and FRG required for half-maximal inhibition (IC50) were 181 and 59 mg/kg, respectively. FRG exhibited significantly stronger antinociceptive activity than RG. In the acetic acid-induced abdominal constriction response, the IC50 values of RG and FRG were 153 and 27 mg/kg, respectively. Although both RG and FRG were able to suppress production of nitric oxide in the LPS-stimulated RAW264.7 macrophage cells, the suppressive activity of FRG appeared to be stronger than that of RG. However, RG and FRG showed similar anti-angiogenic activity. Conclusions FRG possesses enhanced anti-inflammatory and antinociceptive activity but similar anti-angiogenic activity than RG. © 2012 The Authors. JPP © 2012 Royal Pharmaceutical Society. | - |
dc.format.extent | 7 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Royal Pharmaceutical Society | - |
dc.title | Enhancement of anti-inflammatory and antinociceptive actions of red ginseng extract by fermentation | - |
dc.type | Article | - |
dc.publisher.location | 미국 | - |
dc.identifier.doi | 10.1111/j.2042-7158.2012.01460.x | - |
dc.identifier.scopusid | 2-s2.0-84862812499 | - |
dc.identifier.wosid | 000302466100017 | - |
dc.identifier.bibliographicCitation | Journal of Pharmacy and Pharmacology, v.64, no.5, pp 756 - 762 | - |
dc.citation.title | Journal of Pharmacy and Pharmacology | - |
dc.citation.volume | 64 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 756 | - |
dc.citation.endPage | 762 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordPlus | antiinflammatory agent | - |
dc.subject.keywordPlus | antinociceptive agent | - |
dc.subject.keywordPlus | dexamethasone | - |
dc.subject.keywordPlus | fermented red ginseng extract | - |
dc.subject.keywordPlus | indometacin | - |
dc.subject.keywordPlus | nitrate | - |
dc.subject.keywordPlus | nitric oxide | - |
dc.subject.keywordPlus | plant extract | - |
dc.subject.keywordPlus | red ginseng extract | - |
dc.subject.keywordPlus | unclassified drug | - |
dc.subject.keywordPlus | abdominal wall musculature | - |
dc.subject.keywordPlus | animal cell | - |
dc.subject.keywordPlus | animal experiment | - |
dc.subject.keywordPlus | animal model | - |
dc.subject.keywordPlus | antiinflammatory activity | - |
dc.subject.keywordPlus | antinociception | - |
dc.subject.keywordPlus | article | - |
dc.subject.keywordPlus | blood vessel permeability | - |
dc.subject.keywordPlus | controlled study | - |
dc.subject.keywordPlus | fermentation | - |
dc.subject.keywordPlus | ginseng | - |
dc.subject.keywordPlus | IC 50 | - |
dc.subject.keywordPlus | in vivo study | - |
dc.subject.keywordPlus | inflammation | - |
dc.subject.keywordPlus | macrophage activation | - |
dc.subject.keywordPlus | muscle contraction | - |
dc.subject.keywordPlus | nonhuman | - |
dc.subject.keywordPlus | pain | - |
dc.subject.keywordPlus | rat | - |
dc.subject.keywordPlus | red ginseng | - |
dc.subject.keywordPlus | Abdominal Pain | - |
dc.subject.keywordPlus | Acetic Acid | - |
dc.subject.keywordPlus | Analgesics | - |
dc.subject.keywordPlus | Angiogenesis Inhibitors | - |
dc.subject.keywordPlus | Animals | - |
dc.subject.keywordPlus | Anti-Inflammatory Agents | - |
dc.subject.keywordPlus | Carrageenan | - |
dc.subject.keywordPlus | Chick Embryo | - |
dc.subject.keywordPlus | Chorioallantoic Membrane | - |
dc.subject.keywordPlus | Fermentation | - |
dc.subject.keywordPlus | Inflammation | - |
dc.subject.keywordPlus | Lipopolysaccharides | - |
dc.subject.keywordPlus | Macrophages | - |
dc.subject.keywordPlus | Male | - |
dc.subject.keywordPlus | Mice | - |
dc.subject.keywordPlus | Mice, Inbred ICR | - |
dc.subject.keywordPlus | Nitrites | - |
dc.subject.keywordPlus | Panax | - |
dc.subject.keywordPlus | Permeability | - |
dc.subject.keywordPlus | Phytotherapy | - |
dc.subject.keywordPlus | Plant Preparations | - |
dc.subject.keywordAuthor | anti-inflammatory | - |
dc.subject.keywordAuthor | antinociceptive | - |
dc.subject.keywordAuthor | Bifidobacterium | - |
dc.subject.keywordAuthor | fermentation | - |
dc.subject.keywordAuthor | red ginseng | - |
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