Constituents of Pyrus pyrifolia with inhibitory activity on the NO production and the expression of iNOS and COX-2 in macrophages and microglia
DC Field | Value | Language |
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dc.contributor.author | Yoo J.H. | - |
dc.contributor.author | Yang K.S. | - |
dc.date.available | 2021-02-22T13:03:37Z | - |
dc.date.issued | 2012-09 | - |
dc.identifier.issn | 1226-3907 | - |
dc.identifier.uri | https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/12397 | - |
dc.description.abstract | It is well known that inflammation is associated with neurodegenerative disorders, including Alzheimer's disease, Parkinson's disease and ischemia. Nitric oxide (NO), a pro-inflammatory mediator, is produced by inducible NO synthase (iNOS) in microglia as well as macrophages and appears to account for neurodegeneration. In this study, we aimed to isolate NO inhibitors from Pyrus pyrifolia by activity guided purification. As a result, we identified daucosterol and β-sitosterol, which have not been isolated from this plant before. This article also describes NO inhibitory activities of the methanol extract of Pyrus pyrifolia fruit and the isolated compounds from this, which are lupeol, betulin, betulinic acid, β-sitosterol and daucosterol, in LPSactivated RAW 264.7 and BV2 cell lines. Western blot analysis was performed to clarify the underlying mechanism of NO inhibition in the two cell lines. | - |
dc.format.extent | 7 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | 한국생약학회 | - |
dc.title | Constituents of Pyrus pyrifolia with inhibitory activity on the NO production and the expression of iNOS and COX-2 in macrophages and microglia | - |
dc.type | Article | - |
dc.publisher.location | 대한민국 | - |
dc.identifier.scopusid | 2-s2.0-84869797052 | - |
dc.identifier.bibliographicCitation | Natural Product Sciences, v.18, no.3, pp 183 - 189 | - |
dc.citation.title | Natural Product Sciences | - |
dc.citation.volume | 18 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 183 | - |
dc.citation.endPage | 189 | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART001697916 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.subject.keywordPlus | betulic acid | - |
dc.subject.keywordPlus | betulin | - |
dc.subject.keywordPlus | cyclooxygenase 2 | - |
dc.subject.keywordPlus | daucosterol | - |
dc.subject.keywordPlus | inducible nitric oxide synthase | - |
dc.subject.keywordPlus | lupeol | - |
dc.subject.keywordPlus | natural product | - |
dc.subject.keywordPlus | nitric oxide | - |
dc.subject.keywordPlus | sitosterol | - |
dc.subject.keywordPlus | animal cell | - |
dc.subject.keywordPlus | article | - |
dc.subject.keywordPlus | carbon nuclear magnetic resonance | - |
dc.subject.keywordPlus | controlled study | - |
dc.subject.keywordPlus | cytokine production | - |
dc.subject.keywordPlus | drug structure | - |
dc.subject.keywordPlus | electrospray mass spectrometry | - |
dc.subject.keywordPlus | enzyme activity | - |
dc.subject.keywordPlus | enzyme inhibition | - |
dc.subject.keywordPlus | macrophage | - |
dc.subject.keywordPlus | microglia | - |
dc.subject.keywordPlus | mouse | - |
dc.subject.keywordPlus | nonhuman | - |
dc.subject.keywordPlus | phytochemistry | - |
dc.subject.keywordPlus | protein expression | - |
dc.subject.keywordPlus | proton nuclear magnetic resonance | - |
dc.subject.keywordPlus | Pyrus | - |
dc.subject.keywordPlus | Pyrus pyrifolia | - |
dc.subject.keywordPlus | Western blotting | - |
dc.subject.keywordAuthor | Macrophage | - |
dc.subject.keywordAuthor | Microglia | - |
dc.subject.keywordAuthor | Nitric oxide | - |
dc.subject.keywordAuthor | Pyrus pyrifolia | - |
dc.identifier.url | https://scienceon.kisti.re.kr/srch/selectPORSrchArticle.do?cn=JAKO201229140688307&SITE=CLICK | - |
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