LL-37 suppresses sodium nitroprusside-induced apoptosis of systemic sclerosis dermal fibroblasts
DC Field | Value | Language |
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dc.contributor.author | Kim, Hee Jung | - |
dc.contributor.author | Cho, Dae Ho | - |
dc.contributor.author | Lee, Kyung Jin | - |
dc.contributor.author | Cho, Chul Soo | - |
dc.contributor.author | Bang, Sa Ik | - |
dc.contributor.author | Cho, Baik Kee | - |
dc.contributor.author | Park, Hyun Jeong | - |
dc.date.available | 2021-02-22T13:16:19Z | - |
dc.date.issued | 2011-10 | - |
dc.identifier.issn | 0906-6705 | - |
dc.identifier.issn | 1600-0625 | - |
dc.identifier.uri | https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/12485 | - |
dc.description.abstract | The human cathelicidin antimicrobial peptide LL-37 regulates apoptosis of several cell types. Defective apoptosis of skin fibroblasts may contribute to systemic sclerosis (SSc). Here, we show that LL-37 inhibited apoptosis of SSc fibroblasts and identified the signalling pathways by which LL-37 mediates apoptosis. Immunohistochemistry showed that cathelicidin expression was enhanced in SSc patients compared with healthy controls. In addition, LL-37 decreased sodium nitroprusside (SNP)-induced apoptosis of SSc fibroblasts. LL-37 significantly increased expression of Bcl-2 and decreased levels of BAX protein. Pretreatment with LL-37 decreased activation of caspase-3 following SNP-treatment. Moreover, exposure of SSc fibroblasts to LL-37 resulted in increased expression of COX-2 and stimulation of prostaglandin E(2) (PGE(2)). Furthermore, LL-37 induced phosphorylation of ERK and the ERK inhibitor PD98059 blocked the inhibitory effect of LL-37 on apoptosis. Our data indicate that LL-37 may be associated with skin sclerosis by inhibiting apoptosis of dermal fibroblasts. | - |
dc.format.extent | 3 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | WILEY-BLACKWELL | - |
dc.title | LL-37 suppresses sodium nitroprusside-induced apoptosis of systemic sclerosis dermal fibroblasts | - |
dc.type | Article | - |
dc.publisher.location | 미국 | - |
dc.identifier.doi | 10.1111/j.1600-0625.2011.01327.x | - |
dc.identifier.scopusid | 2-s2.0-80052968673 | - |
dc.identifier.wosid | 000295012600036 | - |
dc.identifier.bibliographicCitation | EXPERIMENTAL DERMATOLOGY, v.20, no.10, pp 843 - 845 | - |
dc.citation.title | EXPERIMENTAL DERMATOLOGY | - |
dc.citation.volume | 20 | - |
dc.citation.number | 10 | - |
dc.citation.startPage | 843 | - |
dc.citation.endPage | 845 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Dermatology | - |
dc.relation.journalWebOfScienceCategory | Dermatology | - |
dc.subject.keywordPlus | CATHELICIDIN ANTIMICROBIAL PEPTIDE | - |
dc.subject.keywordPlus | CELL-DEATH | - |
dc.subject.keywordPlus | SKIN | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | KERATINOCYTES | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | MECHANISMS | - |
dc.subject.keywordPlus | INHIBIT | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordAuthor | antimicrobial peptide | - |
dc.subject.keywordAuthor | apoptosis | - |
dc.subject.keywordAuthor | human dermal fibroblasts | - |
dc.subject.keywordAuthor | LL-37 | - |
dc.subject.keywordAuthor | systemic sclerosis | - |
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