Anti-inflammatory Activity of n-Propyl Gallate Through Down-regulation of NF-kappa B and JNK Pathways
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Jung, Hyun-Joo | - |
dc.contributor.author | Kim, Su-Jung | - |
dc.contributor.author | Jeon, Woo-Kwang | - |
dc.contributor.author | Kim, Byung-Chul | - |
dc.contributor.author | Ahn, Kisup | - |
dc.contributor.author | Kim, Kyunghoon | - |
dc.contributor.author | Kim, Young-Myeong | - |
dc.contributor.author | Park, Eun-Hee | - |
dc.contributor.author | Lim, Chang-Jin | - |
dc.date.available | 2021-02-22T13:16:21Z | - |
dc.date.issued | 2011-10 | - |
dc.identifier.issn | 0360-3997 | - |
dc.identifier.issn | 1573-2576 | - |
dc.identifier.uri | https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/12488 | - |
dc.description.abstract | The present study aimed to assess anti-inflammatory activity and underlying mechanism of n-propyl gallate, the n-propyl ester of gallic acid. n-Propyl gallate was shown to contain anti-inflammatory activity using two experimental animal models, acetic acid-induced permeability model in mice, and air pouch model in rats. It suppressed production of nitric oxide and induction of inducible nitric oxide synthase and cyclooxygenase-2 in the lipopolysaccharide (LPS)-stimulated RAW264.7 macrophage cells. It was able to diminish reactive oxygen species level elevated in the LPS-stimulated RAW264.7 macrophage cells. It also suppressed gelatinolytic activity of matrix metalloproteinase-9 enhanced in the LPS-stimulated RAW264.7 macrophage cells. It inhibited inhibitory kappa B-alpha degradation and enhanced NF-kappa B promoter activity in the stimulated macrophage cells. It was able to suppress phosphorylation of c-Jun NH(2)-terminal kinase 1/2 (JNK1/2) and activation of c-Jun promoter activity in the stimulated macrophage cells. In brief, n-propyl gallate possesses anti-inflammatory activity via down-regulation of NF-kappa B and JNK pathways. | - |
dc.format.extent | 10 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | SPRINGER/PLENUM PUBLISHERS | - |
dc.title | Anti-inflammatory Activity of n-Propyl Gallate Through Down-regulation of NF-kappa B and JNK Pathways | - |
dc.type | Article | - |
dc.publisher.location | 미국 | - |
dc.identifier.doi | 10.1007/s10753-010-9241-0 | - |
dc.identifier.scopusid | 2-s2.0-80655135569 | - |
dc.identifier.wosid | 000294820200007 | - |
dc.identifier.bibliographicCitation | INFLAMMATION, v.34, no.5, pp 352 - 361 | - |
dc.citation.title | INFLAMMATION | - |
dc.citation.volume | 34 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 352 | - |
dc.citation.endPage | 361 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalResearchArea | Immunology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.subject.keywordPlus | NITRIC-OXIDE SYNTHASE | - |
dc.subject.keywordPlus | MATRIX METALLOPROTEINASES | - |
dc.subject.keywordPlus | TYROSINE PHOSPHORYLATION | - |
dc.subject.keywordPlus | INDUCED APOPTOSIS | - |
dc.subject.keywordPlus | OXIDATIVE STRESS | - |
dc.subject.keywordPlus | INTERFERON-GAMMA | - |
dc.subject.keywordPlus | TEA POLYPHENOL | - |
dc.subject.keywordPlus | CELL-LINES | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | MACROPHAGES | - |
dc.subject.keywordAuthor | anti-inflammatory | - |
dc.subject.keywordAuthor | cyclooxygenase-2 | - |
dc.subject.keywordAuthor | matrix metalloproteinase-9 | - |
dc.subject.keywordAuthor | nitric oxide | - |
dc.subject.keywordAuthor | n-propyl gallate | - |
dc.subject.keywordAuthor | reactive oxygen species | - |
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