Vascular tube formation and angiogenesis induced by polyvinylpyrrolidone-coated silver nanoparticles
DC Field | Value | Language |
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dc.contributor.author | Kang, Kyeongah | - |
dc.contributor.author | Lim, Dae-Hyoun | - |
dc.contributor.author | Choi, In-Hong | - |
dc.contributor.author | Kang, Taegyeong | - |
dc.contributor.author | Lee, Kangtaek | - |
dc.contributor.author | Moon, Eun-Yi | - |
dc.contributor.author | Yang, Young | - |
dc.contributor.author | Lee, Myeong-Sok | - |
dc.contributor.author | Lim, Jong-Seok | - |
dc.date.available | 2021-02-22T13:16:27Z | - |
dc.date.issued | 2011-09 | - |
dc.identifier.issn | 0378-4274 | - |
dc.identifier.issn | 1879-3169 | - |
dc.identifier.uri | https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/12496 | - |
dc.description.abstract | Silver nanoparticles (AgNPs) are one of the most commonly used nanomaterials due to their antibacterial properties. In this study, we examined the effects of polyvinylpyrrolidone (PVP)-coated AgNPs (average size 2.3 nm) on angiogenesis in both an in vivo model and an in vitro endothelial cell line, SVEC4-10. Increased angiogenesis was detected around the injection site of AgNP-containing Matrigel in vivo. AgNPs also increased the infiltration of endothelial cells and the hemoglobin (Hb) content in AgNP-Matrigel plugs implanted into mice. AgNPs induced endothelial cell tube formation on growth factor-reduced Matrigel, production of reactive oxygen species (ROS), and production of angiogenic factors, such as vascular endothelial growth factor (VEGF) and nitric oxide (NO), in SVEC4-10 cells. In addition, AgNPs promoted the activation of FAK, Akt, ERK1/2, and p38, which are all involved in VEGF receptor (VEGFR)-mediated signaling. Finally, AgNP-treated tumors caused angiogenesis around tumors in B16F10 melanomas after they were injected into mice, and the Hb concentration in the tumors increased in a concentration-dependent manner with AgNP treatment. Thus, our study suggests that exposure to AgNPs can cause angiogenesis through the production of angiogenic factors. (C) 2011 Elsevier Ireland Ltd. All rights reserved. | - |
dc.format.extent | 8 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | ELSEVIER IRELAND LTD | - |
dc.title | Vascular tube formation and angiogenesis induced by polyvinylpyrrolidone-coated silver nanoparticles | - |
dc.type | Article | - |
dc.publisher.location | 아일랜드 | - |
dc.identifier.doi | 10.1016/j.toxlet.2011.05.1033 | - |
dc.identifier.scopusid | 2-s2.0-79960910218 | - |
dc.identifier.wosid | 000294578500001 | - |
dc.identifier.bibliographicCitation | TOXICOLOGY LETTERS, v.205, no.3, pp 227 - 234 | - |
dc.citation.title | TOXICOLOGY LETTERS | - |
dc.citation.volume | 205 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 227 | - |
dc.citation.endPage | 234 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Toxicology | - |
dc.relation.journalWebOfScienceCategory | Toxicology | - |
dc.subject.keywordPlus | OXIDATIVE STRESS | - |
dc.subject.keywordPlus | APOPTOSIS | - |
dc.subject.keywordPlus | MECHANISMS | - |
dc.subject.keywordPlus | TOXICITY | - |
dc.subject.keywordAuthor | Silver nanoparticles | - |
dc.subject.keywordAuthor | Matrigel plug | - |
dc.subject.keywordAuthor | Angiogenesis | - |
dc.subject.keywordAuthor | Vascular endothelial growth factor | - |
dc.subject.keywordAuthor | VEGF signaling | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/abs/pii/S0378427411012513?via%3Dihub | - |
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