In Vitro Antiinflammatory Activity of a New Sesquiterpene Lactone Isolated from Siegesbeckia glabrescens
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Li, Hua | - |
dc.contributor.author | Kim, Jae Yeon | - |
dc.contributor.author | Hyeon, Jinseong | - |
dc.contributor.author | Lee, Hwa Jin | - |
dc.contributor.author | Ryu, Jae-Ha | - |
dc.date.available | 2021-02-22T13:16:37Z | - |
dc.date.issued | 2011-09 | - |
dc.identifier.issn | 0951-418X | - |
dc.identifier.issn | 1099-1573 | - |
dc.identifier.uri | https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/12511 | - |
dc.description.abstract | A new sesquiterpene lactone was isolated from Siegesbeckia glabrescens as an inhibitor of nitric oxide and prostaglandin E-2 synthesis in the LPS-activated RAW264.7 macrophage cell line. It dose-dependently decreased the protein and mRNA levels of inducible nitric oxide synthase and cyclooxygenase-2. Reporter gene assay revealed that the compound attenuated the LPS-induced DNA transcriptional activity of nuclear factor-kappa B (NF-kappa B). In addition, it inhibited the nuclear translocation of the p65 subunit of NF-kappa B by blocking the inhibitory kappa B-alpha degradation. This compound from Siegesbeckia glabrescens might be beneficial for the treatment of inflammation-related diseases. Copyright (C) 2011 John Wiley & Sons, Ltd. | - |
dc.format.extent | 5 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | WILEY | - |
dc.title | In Vitro Antiinflammatory Activity of a New Sesquiterpene Lactone Isolated from Siegesbeckia glabrescens | - |
dc.type | Article | - |
dc.publisher.location | 미국 | - |
dc.identifier.doi | 10.1002/ptr.3420 | - |
dc.identifier.scopusid | 2-s2.0-80051843305 | - |
dc.identifier.wosid | 000294975600009 | - |
dc.identifier.bibliographicCitation | PHYTOTHERAPY RESEARCH, v.25, no.9, pp 1323 - 1327 | - |
dc.citation.title | PHYTOTHERAPY RESEARCH | - |
dc.citation.volume | 25 | - |
dc.citation.number | 9 | - |
dc.citation.startPage | 1323 | - |
dc.citation.endPage | 1327 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.subject.keywordPlus | NITRIC-OXIDE SYNTHASE | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | CYCLOOXYGENASE | - |
dc.subject.keywordPlus | INFLAMMATION | - |
dc.subject.keywordPlus | MACROPHAGES | - |
dc.subject.keywordPlus | SUPPRESSION | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordAuthor | nitric oxide | - |
dc.subject.keywordAuthor | prostaglandin E-2 | - |
dc.subject.keywordAuthor | nuclear factor-kappa B | - |
dc.subject.keywordAuthor | Siegesbeckia glabrescens | - |
dc.subject.keywordAuthor | sesquiterpenes | - |
dc.subject.keywordAuthor | inhibitor | - |
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