Detailed Information

Cited 0 time in webofscience Cited 8 time in scopus
Metadata Downloads

Direct Response Elements of BMP within the PV.1A Promoter Are Essential for Its Transcriptional Regulation during Early Xenopus Development

Full metadata record
DC FieldValueLanguage
dc.contributor.authorLee, Hyun-Shik-
dc.contributor.authorLee, Sung-Young-
dc.contributor.authorLee, Hyosang-
dc.contributor.authorHwang, Yoo-Seok-
dc.contributor.authorCha, Sang-Wook-
dc.contributor.authorPark, Soochul-
dc.contributor.authorLee, Jae-Yong-
dc.contributor.authorPark, Jae-Bong-
dc.contributor.authorKim, SungChan-
dc.contributor.authorPark, Mae Ja-
dc.contributor.authorKim, Jaebong-
dc.date.available2021-02-22T13:16:42Z-
dc.date.created2020-09-03-
dc.date.issued2011-08-
dc.identifier.issn1932-6203-
dc.identifier.urihttps://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/12519-
dc.description.abstractXvent homeobox genes encode transcription factors that repress organizer genes and are essential for dorsoventral specification during early embryogenesis in Xenopus. In contrast to the Xvent-2 gene subfamily, Xvent-1 subfamily members, including PV.1A, have been proposed as indirect targets of Bone Morphogenetic Protein-4 (BMP-4) signaling. Because PV.1A is a critical downstream mediator of, and tightly regulated by, BMP-4 signaling, we hypothesized that its promoter contains a direct BMP-4 response element to effect this transcriptional regulation. We demonstrate that direct regulation by BMP-4 is necessary for transcription of PV.1A: its proximal promoter contains cis-acting binding elements for Smads and Oaz crucial to induction in response to BMP-4 signaling. In addition to these direct cis-acting BMP-4 responsive elements, an indirect Xvent-2 response element and several repressive elements exist in the PV.1A promoter to regulate its transcription. In summary, PV.1A undergoes combinatorial regulation during early Xenopus development as both the direct target of BMP-4 signaling and as the direct and indirect target of positive and negative regulatory factors.-
dc.language영어-
dc.language.isoen-
dc.publisherPUBLIC LIBRARY SCIENCE-
dc.titleDirect Response Elements of BMP within the PV.1A Promoter Are Essential for Its Transcriptional Regulation during Early Xenopus Development-
dc.typeArticle-
dc.contributor.affiliatedAuthorPark, Soochul-
dc.identifier.doi10.1371/journal.pone.0022621-
dc.identifier.scopusid2-s2.0-79961036286-
dc.identifier.wosid000293558900022-
dc.identifier.bibliographicCitationPLOS ONE, v.6, no.8-
dc.relation.isPartOfPLOS ONE-
dc.citation.titlePLOS ONE-
dc.citation.volume6-
dc.citation.number8-
dc.type.rimsART-
dc.type.docTypeArticle-
dc.description.journalClass1-
dc.description.isOpenAccessN-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaScience & Technology - Other Topics-
dc.relation.journalWebOfScienceCategoryMultidisciplinary Sciences-
dc.subject.keywordPlusBONE MORPHOGENETIC PROTEINS-
dc.subject.keywordPlusHOMEOBOX GENE-
dc.subject.keywordPlusXVENT-2-
dc.subject.keywordPlusMESODERM-
dc.subject.keywordPlusINDUCTION-
dc.subject.keywordPlusBINDING-
dc.subject.keywordPlusEXPRESSION-
dc.subject.keywordPlusEMBRYOS-
dc.subject.keywordPlusFAMILY-
dc.subject.keywordPlusXOM-
dc.identifier.urlhttps://journals.plos.org/plosone/article?id=10.1371/journal.pone.0022621-
Files in This Item
Go to Link
Appears in
Collections
이과대학 > 생명시스템학부 > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Related Researcher

Researcher Park, Soo Chul photo

Park, Soo Chul
이과대학 (생명시스템학부)
Read more

Altmetrics

Total Views & Downloads

BROWSE