L-Kynurenine-induced apoptosis in human NK cells is mediated by reactive oxygen species
DC Field | Value | Language |
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dc.contributor.author | Song, Hyunkeun | - |
dc.contributor.author | Park, Hyunjin | - |
dc.contributor.author | Kim, Yeong-Seok | - |
dc.contributor.author | Kim, Kwang Dong | - |
dc.contributor.author | Lee, Hyun-Kyung | - |
dc.contributor.author | Cho, Dae-Ho | - |
dc.contributor.author | Yang, Jae-Wook | - |
dc.contributor.author | Hur, Dae Young | - |
dc.date.available | 2021-02-22T13:16:49Z | - |
dc.date.issued | 2011-08 | - |
dc.identifier.issn | 1567-5769 | - |
dc.identifier.issn | 1878-1705 | - |
dc.identifier.uri | https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/12530 | - |
dc.description.abstract | Recent studies have shown that indoleamine 2,3-dioxygenase (IDO) plays a pivotal role in the modulation of immune response against tumor and virus infection. Here we demonstrate the pro-apoptotic effect of L-kynurenine, a tryptophan catabolite of IDO, on human NK cell line, NK92 MI. Treatment with L-kynurenine dose-dependently induced growth inhibition and apoptosis in NK92 MI cells. Treatment with the antioxidant NAC completely protected cells from L-kynurenine-induced apoptosis. Moreover, we found that treatment with Z-VAD-fmk and ZB4 slightly inhibited L-kynurenine-induced apoptosis, suggesting that L-kynurenine-induced apoptosis in NK cells occurs primarily through an ROS mediated pathway. We observed that the presence of NAC blocks cytochrome c release and activation of caspase-3 during L-kynurenine-induced apoptosis. Overall, we conclude that L-kynurenine resulting from 100 can cause cell death via ROS pathway in NK cells. Our findings provide a new insight into the interaction between NK cells and IDO positive cancer cells in regulating immune responses. Crown Copyright (C) 2011 Published by Elsevier B.V. All rights reserved. | - |
dc.format.extent | 7 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | ELSEVIER SCIENCE BV | - |
dc.title | L-Kynurenine-induced apoptosis in human NK cells is mediated by reactive oxygen species | - |
dc.type | Article | - |
dc.publisher.location | 네델란드 | - |
dc.identifier.doi | 10.1016/j.intimp.2011.02.005 | - |
dc.identifier.scopusid | 2-s2.0-84860388908 | - |
dc.identifier.wosid | 000293723400005 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL IMMUNOPHARMACOLOGY, v.11, no.8, pp 932 - 938 | - |
dc.citation.title | INTERNATIONAL IMMUNOPHARMACOLOGY | - |
dc.citation.volume | 11 | - |
dc.citation.number | 8 | - |
dc.citation.startPage | 932 | - |
dc.citation.endPage | 938 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Immunology | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.subject.keywordPlus | NATURAL-KILLER-CELLS | - |
dc.subject.keywordPlus | INDOLEAMINE 2,3-DIOXYGENASE | - |
dc.subject.keywordPlus | T-CELL | - |
dc.subject.keywordPlus | TRYPTOPHAN CATABOLISM | - |
dc.subject.keywordPlus | DENDRITIC CELLS | - |
dc.subject.keywordPlus | INTERFERON-GAMMA | - |
dc.subject.keywordPlus | INHIBITION | - |
dc.subject.keywordPlus | PROLIFERATION | - |
dc.subject.keywordPlus | METABOLITES | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordAuthor | NK cell | - |
dc.subject.keywordAuthor | ROS | - |
dc.subject.keywordAuthor | IDO | - |
dc.subject.keywordAuthor | L-Kynurenine | - |
dc.subject.keywordAuthor | Apoptosis | - |
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