A Prenylated Flavan from Broussonetia kazinoki Prevents Cytokine-Induced beta-Cell Death through Suppression of Nuclear Factor-kappa B Activity
DC Field | Value | Language |
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dc.contributor.author | Bae, Ui-Jin | - |
dc.contributor.author | Lee, Da Yeon | - |
dc.contributor.author | Song, Mi-Young | - |
dc.contributor.author | Lee, Sang-Myeong | - |
dc.contributor.author | Park, Jin-Woo | - |
dc.contributor.author | Ryu, Jae-Ha | - |
dc.contributor.author | Park, Byung-Hyun | - |
dc.date.available | 2021-02-22T13:16:59Z | - |
dc.date.issued | 2011-07 | - |
dc.identifier.issn | 0918-6158 | - |
dc.identifier.issn | 1347-5215 | - |
dc.identifier.uri | https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/12546 | - |
dc.description.abstract | The generation of nitric oxide (NO) via inducible NO synthase (iNOS) and reactive oxygen species plays a key role in cytokine-mediated pancreatic beta-cell damage. Oxidative stress due to reactive oxygen species activates the nuclear factor-kappa B (NF-kappa B) transcription factor, which regulates iNOS expression. In this regard, suppression of the NF-kappa B pathway is a novel strategy for protecting beta-cells from damage. This study was performed to explore the effects of kazinol U, a prenylated flavan from Broussonetia kazinoki, on the NF-kappa B activation pathway in interleukin-1 beta (IL-1 beta)- and interferon-gamma (IFN-gamma)-treated beta-cells. The cytotoxic effects of cytokines were completely abolished when RINm5F cells or islets were pretreated with kazinol U. Kazinol U inhibited the nuclear translocation and DNA binding of NF-kappa B subunits, which correlated with the inhibitory effects on I kappa B kinase (IKK) phosphorylation and I kappa B alpha degradation. In addition, kazinol U suppressed NO and hydrogen peroxide production and apoptotic cell death by cytokines in RINm5F cells. The protective effects of kazinol U were further demonstrated by normal insulin secretion of cytokine-treated islets in response to glucose. Taken together, these results suggest that using kazinol U to block the NF-kappa B pathway in pancreatic beta-cells reduces cell damage. Therefore, kazinol U may have therapeutic value in delaying pancreatic beta-cell destruction in type 1 diabetes. | - |
dc.format.extent | 6 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | PHARMACEUTICAL SOC JAPAN | - |
dc.title | A Prenylated Flavan from Broussonetia kazinoki Prevents Cytokine-Induced beta-Cell Death through Suppression of Nuclear Factor-kappa B Activity | - |
dc.type | Article | - |
dc.publisher.location | 일본 | - |
dc.identifier.doi | 10.1248/bpb.34.1026 | - |
dc.identifier.scopusid | 2-s2.0-79960289230 | - |
dc.identifier.wosid | 000292342100014 | - |
dc.identifier.bibliographicCitation | BIOLOGICAL & PHARMACEUTICAL BULLETIN, v.34, no.7, pp 1026 - 1031 | - |
dc.citation.title | BIOLOGICAL & PHARMACEUTICAL BULLETIN | - |
dc.citation.volume | 34 | - |
dc.citation.number | 7 | - |
dc.citation.startPage | 1026 | - |
dc.citation.endPage | 1031 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.subject.keywordPlus | OXYGEN-FREE RADICALS | - |
dc.subject.keywordPlus | NITRIC-OXIDE | - |
dc.subject.keywordPlus | ANTIOXIDANT ENZYMES | - |
dc.subject.keywordPlus | MEDIATED TOXICITY | - |
dc.subject.keywordPlus | RINM5F CELLS | - |
dc.subject.keywordPlus | PROTECTS | - |
dc.subject.keywordPlus | TYPE-1 | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | PATHWAY | - |
dc.subject.keywordAuthor | beta-cell | - |
dc.subject.keywordAuthor | Broussonetia kazinoki | - |
dc.subject.keywordAuthor | cytokine | - |
dc.subject.keywordAuthor | nuclear factor-kappa B | - |
dc.subject.keywordAuthor | reactive oxygen species | - |
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