Romo1 is a negative-feedback regulator of Myc
DC Field | Value | Language |
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dc.contributor.author | Lee, Seung Baek | - |
dc.contributor.author | Kim, Jung Jin | - |
dc.contributor.author | Chung, Jin Sil | - |
dc.contributor.author | Lee, Myeong-Sok | - |
dc.contributor.author | Lee, Kee-Ho | - |
dc.contributor.author | Kim, Byung Soo | - |
dc.contributor.author | Tansey, William P. | - |
dc.contributor.author | Yoo, Young Do | - |
dc.date.available | 2021-02-22T13:17:05Z | - |
dc.date.issued | 2011-06 | - |
dc.identifier.issn | 0021-9533 | - |
dc.identifier.issn | 1477-9137 | - |
dc.identifier.uri | https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/12555 | - |
dc.description.abstract | Degradation of Myc protein is mediated by E3 ubiquitin ligases, including SCF(Fbw7) and SCF(Skp2), but much remains unknown about the mechanism of S-phase kinase-associated protein (Skp2)-mediated Myc degradation. In the present study, we show that upregulated Myc protein, which triggers the G1-S phase progression in response to growth-stimulatory signals, induces reactive oxygen species modulator 1 (Romo1) expression. Romo1 subsequently triggers Skp2-mediated ubiquitylation and degradation of Myc by a mechanism not previously reported in normal lung fibroblasts. We also show that reactive oxygen species (ROS) derived from steady-state Romo1 expression are necessary for cell cycle entry of quiescent cells. From this study, we suggest that the generation of ROS mediated by pre-existing Romo1 protein is required for Myc induction. Meanwhile, Romo1 expression induced by Myc during G1 phase stimulates Skp2-mediated Myc degradation in a negative-feedback mechanism. | - |
dc.format.extent | 14 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | COMPANY OF BIOLOGISTS LTD | - |
dc.title | Romo1 is a negative-feedback regulator of Myc | - |
dc.type | Article | - |
dc.publisher.location | 영국 | - |
dc.identifier.doi | 10.1242/jcs.079996 | - |
dc.identifier.scopusid | 2-s2.0-79958138508 | - |
dc.identifier.wosid | 000290617800015 | - |
dc.identifier.bibliographicCitation | JOURNAL OF CELL SCIENCE, v.124, no.11, pp 1911 - 1924 | - |
dc.citation.title | JOURNAL OF CELL SCIENCE | - |
dc.citation.volume | 124 | - |
dc.citation.number | 11 | - |
dc.citation.startPage | 1911 | - |
dc.citation.endPage | 1924 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.subject.keywordPlus | F-BOX PROTEIN | - |
dc.subject.keywordPlus | UBIQUITIN-MEDIATED PROTEOLYSIS | - |
dc.subject.keywordPlus | GLYCOGEN-SYNTHASE KINASE-3 | - |
dc.subject.keywordPlus | CELL-CYCLE PROGRESSION | - |
dc.subject.keywordPlus | C-MYC | - |
dc.subject.keywordPlus | OXIDATIVE STRESS | - |
dc.subject.keywordPlus | ROS PRODUCTION | - |
dc.subject.keywordPlus | PHOSPHORYLATION | - |
dc.subject.keywordPlus | DEGRADATION | - |
dc.subject.keywordPlus | SKP2 | - |
dc.subject.keywordAuthor | Myc | - |
dc.subject.keywordAuthor | Romo1 | - |
dc.subject.keywordAuthor | ROS | - |
dc.subject.keywordAuthor | Skp2 | - |
dc.identifier.url | https://jcs.biologists.org/content/124/11/1911 | - |
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