Differential Impacts of Insulin-Like Growth Factor-Binding Protein-3 (IGFBP-3) in Epithelial IGF-Induced Lung Cancer Development
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Woo-Young | - |
dc.contributor.author | Kim, Mi-Jung | - |
dc.contributor.author | Moon, Hojin | - |
dc.contributor.author | Yuan, Ping | - |
dc.contributor.author | Kim, Jin-Soo | - |
dc.contributor.author | Woo, Jong-Kyu | - |
dc.contributor.author | Zhang, Guangcheng | - |
dc.contributor.author | Suh, Young-Ah | - |
dc.contributor.author | Feng, Lei | - |
dc.contributor.author | Behrens, Carmen | - |
dc.contributor.author | Van Pelt, Carolyn S. | - |
dc.contributor.author | Kang, Hyunseok | - |
dc.contributor.author | Lee, J. Jack | - |
dc.contributor.author | Hong, Waun-Ki | - |
dc.contributor.author | Wistuba, Ignacio I. | - |
dc.contributor.author | Lee, Ho-Young | - |
dc.date.available | 2021-02-22T13:17:10Z | - |
dc.date.issued | 2011-06 | - |
dc.identifier.issn | 0013-7227 | - |
dc.identifier.issn | 1945-7170 | - |
dc.identifier.uri | https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/12564 | - |
dc.description.abstract | The IGF axis has been implicated in the risk of various cancers. We previously reported a potential role of tissue-derived IGF in lung tumor formation and progression. However, the role of IGF-binding protein (IGFBP)-3, a major IGFBP, on the activity of tissue-driven IGF in lung cancer development is largely unknown. Here, we show that IGF-I, but not IGF-II, protein levels in non-small-cell lung cancer (NSCLC) were significantly higher than those in normal and hyperplastic bronchial epithelium. We found that IGF-I and IGFBP-3 levels in NSCLC tissue specimens were significantly correlated with phosphorylated IGF-IR (pIGF-IR) expression. We investigated the impact of IGFBP-3 expression on the activity of tissue-driven IGF-I in lung cancer development using mice carrying lung-specific human IGF-I transgene (Tg), a germline-null mutation of IGFBP-3, or both. Compared with wild-type (BP3(+/+)) mice, mice carrying heterozygous (BP3(+/-)) or homozygous (BP3(-/-)) deletion of IGFBP-3 alleles exhibited decreases in circulating IGFBP-3 and IGF-I. Unexpectedly, IGF(Tg) mice with 50% of physiological IGFBP-3 (BP3(+/-); IGF(Tg)) showed higher levels of pIGF-IR/IR and a greater degree of spontaneous or tobacco carcinogen [4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone]-induced lung tumor development and progression than did the IGF(Tg) mice with normal (BP3(+/+); IGF(Tg)) or homozygous deletion of IGFBP-3 (BP3(-/-); IGF(Tg)). These data show that IGF-I is overexpressed in NSCLC, leading to activation of IGF-IR, and that IGFBP-3, depending on its expression level, either inhibits or potentiates IGF-I actions in lung carcinogenesis. (Endocrinology 152: 2164-2173, 2011) | - |
dc.format.extent | 10 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | ENDOCRINE SOC | - |
dc.title | Differential Impacts of Insulin-Like Growth Factor-Binding Protein-3 (IGFBP-3) in Epithelial IGF-Induced Lung Cancer Development | - |
dc.type | Article | - |
dc.publisher.location | 미국 | - |
dc.identifier.doi | 10.1210/en.2010-0693 | - |
dc.identifier.scopusid | 2-s2.0-79956324408 | - |
dc.identifier.wosid | 000290788500004 | - |
dc.identifier.bibliographicCitation | ENDOCRINOLOGY, v.152, no.6, pp 2164 - 2173 | - |
dc.citation.title | ENDOCRINOLOGY | - |
dc.citation.volume | 152 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 2164 | - |
dc.citation.endPage | 2173 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Endocrinology & Metabolism | - |
dc.relation.journalWebOfScienceCategory | Endocrinology & Metabolism | - |
dc.subject.keywordPlus | PROGRAMMED CELL-DEATH | - |
dc.subject.keywordPlus | BREAST-CANCER | - |
dc.subject.keywordPlus | FACTOR-I | - |
dc.subject.keywordPlus | FACTOR BINDING-PROTEIN-3 | - |
dc.subject.keywordPlus | INDEPENDENT MECHANISMS | - |
dc.subject.keywordPlus | SIGNALING PATHWAYS | - |
dc.subject.keywordPlus | RECEPTOR ISOFORMS | - |
dc.subject.keywordPlus | SURFACE BINDING | - |
dc.subject.keywordPlus | PLASMA-LEVELS | - |
dc.subject.keywordPlus | RISK | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
Sookmyung Women's University. Cheongpa-ro 47-gil 100 (Cheongpa-dong 2ga), Yongsan-gu, Seoul, 04310, Korea02-710-9127
Copyright©Sookmyung Women's University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.