Melphalan Modulates the Expression of E7-Specific Biomarkers in E7-Tg Mice
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Eun Jin | - |
dc.contributor.author | Kim, Heejong | - |
dc.contributor.author | Lee, Sojung | - |
dc.contributor.author | Kang, Jeong Woo | - |
dc.contributor.author | Lee, Dong Hun | - |
dc.contributor.author | Choi, Hee Sook | - |
dc.contributor.author | Kim, Jin Man | - |
dc.contributor.author | Yang, Young | - |
dc.contributor.author | Sheen, Yhun Yhong | - |
dc.contributor.author | Park, Sue Nie | - |
dc.contributor.author | Yoon, Do Young | - |
dc.date.available | 2021-02-22T13:47:38Z | - |
dc.date.issued | 2010-07 | - |
dc.identifier.issn | 0250-7005 | - |
dc.identifier.issn | 1791-7530 | - |
dc.identifier.uri | https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/13180 | - |
dc.description.abstract | HPV oncoproteins are selectively retained and expressed in HPV infected carcinoma cells. The oncoprotein interacts with the tumour suppressor Rb, and leads to the progression of oncogenesis. In a previous study, E7 biomarkers were identified in E7 Tg mice. In this study, in order to investigate whether a genotoxic carcinogen would modulate carcinogenesis in the E7-Tg mice, an anticancer drug, melphalan, was intraperitoneally injected into E7-Tg mice for eight weeks at two-day intervals and then genes and proteins were analysed using Omics approaches and RT-qPCR. RT-qPCR was performed to confirm whether E7 biomarkers would be modulated by inelphalan treatment in E7-Tg mice, revealing that up-regulated E7 markers such as cyclin B1, CD166, and actin alpha 1 were down-regulated, whereas expression of down-regulated E7 markers such as vimentin was restored by melphalan treatment. These results suggest that melphalan inhibits carcinogenesis via modulating E7-specific genes and proteins expressed in the lung tissues of E7 Tg mice. | - |
dc.format.extent | 11 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | INT INST ANTICANCER RESEARCH | - |
dc.title | Melphalan Modulates the Expression of E7-Specific Biomarkers in E7-Tg Mice | - |
dc.type | Article | - |
dc.publisher.location | 그리이스 | - |
dc.identifier.scopusid | 2-s2.0-77955784560 | - |
dc.identifier.wosid | 000280796400041 | - |
dc.identifier.bibliographicCitation | ANTICANCER RESEARCH, v.30, no.7, pp 2773 - 2783 | - |
dc.citation.title | ANTICANCER RESEARCH | - |
dc.citation.volume | 30 | - |
dc.citation.number | 7 | - |
dc.citation.startPage | 2773 | - |
dc.citation.endPage | 2783 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Oncology | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.subject.keywordPlus | LUNG-CANCER | - |
dc.subject.keywordPlus | MULTIPLE-MYELOMA | - |
dc.subject.keywordPlus | TUMOR-CELLS | - |
dc.subject.keywordPlus | APOPTOSIS | - |
dc.subject.keywordPlus | PROTEINS | - |
dc.subject.keywordPlus | DNA | - |
dc.subject.keywordPlus | CARCINOMA | - |
dc.subject.keywordPlus | E7 | - |
dc.subject.keywordPlus | PAPILLOMAVIRUSES | - |
dc.subject.keywordPlus | RESISTANCE | - |
dc.subject.keywordAuthor | Cancer | - |
dc.subject.keywordAuthor | E7 oncogene | - |
dc.subject.keywordAuthor | Melphalan | - |
dc.subject.keywordAuthor | Proteomics | - |
dc.subject.keywordAuthor | Tg mouse | - |
dc.identifier.url | https://ar.iiarjournals.org/content/30/7/2773.short | - |
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