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Melphalan Modulates the Expression of E7-Specific Biomarkers in E7-Tg Mice

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dc.contributor.authorKim, Eun Jin-
dc.contributor.authorKim, Heejong-
dc.contributor.authorLee, Sojung-
dc.contributor.authorKang, Jeong Woo-
dc.contributor.authorLee, Dong Hun-
dc.contributor.authorChoi, Hee Sook-
dc.contributor.authorKim, Jin Man-
dc.contributor.authorYang, Young-
dc.contributor.authorSheen, Yhun Yhong-
dc.contributor.authorPark, Sue Nie-
dc.contributor.authorYoon, Do Young-
dc.date.available2021-02-22T13:47:38Z-
dc.date.issued2010-07-
dc.identifier.issn0250-7005-
dc.identifier.issn1791-7530-
dc.identifier.urihttps://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/13180-
dc.description.abstractHPV oncoproteins are selectively retained and expressed in HPV infected carcinoma cells. The oncoprotein interacts with the tumour suppressor Rb, and leads to the progression of oncogenesis. In a previous study, E7 biomarkers were identified in E7 Tg mice. In this study, in order to investigate whether a genotoxic carcinogen would modulate carcinogenesis in the E7-Tg mice, an anticancer drug, melphalan, was intraperitoneally injected into E7-Tg mice for eight weeks at two-day intervals and then genes and proteins were analysed using Omics approaches and RT-qPCR. RT-qPCR was performed to confirm whether E7 biomarkers would be modulated by inelphalan treatment in E7-Tg mice, revealing that up-regulated E7 markers such as cyclin B1, CD166, and actin alpha 1 were down-regulated, whereas expression of down-regulated E7 markers such as vimentin was restored by melphalan treatment. These results suggest that melphalan inhibits carcinogenesis via modulating E7-specific genes and proteins expressed in the lung tissues of E7 Tg mice.-
dc.format.extent11-
dc.language영어-
dc.language.isoENG-
dc.publisherINT INST ANTICANCER RESEARCH-
dc.titleMelphalan Modulates the Expression of E7-Specific Biomarkers in E7-Tg Mice-
dc.typeArticle-
dc.publisher.location그리이스-
dc.identifier.scopusid2-s2.0-77955784560-
dc.identifier.wosid000280796400041-
dc.identifier.bibliographicCitationANTICANCER RESEARCH, v.30, no.7, pp 2773 - 2783-
dc.citation.titleANTICANCER RESEARCH-
dc.citation.volume30-
dc.citation.number7-
dc.citation.startPage2773-
dc.citation.endPage2783-
dc.type.docTypeArticle-
dc.description.isOpenAccessN-
dc.description.journalRegisteredClasssci-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaOncology-
dc.relation.journalWebOfScienceCategoryOncology-
dc.subject.keywordPlusLUNG-CANCER-
dc.subject.keywordPlusMULTIPLE-MYELOMA-
dc.subject.keywordPlusTUMOR-CELLS-
dc.subject.keywordPlusAPOPTOSIS-
dc.subject.keywordPlusPROTEINS-
dc.subject.keywordPlusDNA-
dc.subject.keywordPlusCARCINOMA-
dc.subject.keywordPlusE7-
dc.subject.keywordPlusPAPILLOMAVIRUSES-
dc.subject.keywordPlusRESISTANCE-
dc.subject.keywordAuthorCancer-
dc.subject.keywordAuthorE7 oncogene-
dc.subject.keywordAuthorMelphalan-
dc.subject.keywordAuthorProteomics-
dc.subject.keywordAuthorTg mouse-
dc.identifier.urlhttps://ar.iiarjournals.org/content/30/7/2773.short-
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