IL-18 Downregulates Collagen Production in Human Dermal Fibroblasts via the ERK Pathway
DC Field | Value | Language |
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dc.contributor.author | Kim, Hee Jung | - |
dc.contributor.author | Song, Seok Bean | - |
dc.contributor.author | Choi, Jung Min | - |
dc.contributor.author | Kim, Kyung Moon | - |
dc.contributor.author | Cho, Baik Kee | - |
dc.contributor.author | Cho, Dae Ho | - |
dc.contributor.author | Park, Hyun Jeong | - |
dc.date.available | 2021-02-22T13:48:30Z | - |
dc.date.issued | 2010-03 | - |
dc.identifier.issn | 0022-202X | - |
dc.identifier.issn | 1523-1747 | - |
dc.identifier.uri | https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/13254 | - |
dc.description.abstract | Excessive accumulation of collagen contributes to the fibrotic process. Several experimental studies have shown that IFN-gamma is effective in preventing fibrogenesis. IL-18, originally identified as an IFN-gamma-inducing factor, is a key mediator of inflammation and host defense responses. In this study, we investigated the regulatory effect of IL-18 on the expression of type I and III collagen genes in dermal fibroblasts. The exposure of human dermal fibroblasts (HDFs) to IL-18 resulted in a reduction of collagen gene expression and production. Also, IL-18 inhibited the fibrogenic cytokine transforming growth factor (TGF)-beta-induced collagen gene expression. Next, to determine the molecular mechanism involved in this regulation, we showed that IL-18-regulated collagen expression was blocked by small interfering RNA (siRNA)-mediated Ets-1 knockdown. Furthermore, we showed that IL-18 induced phosphorylation of extracellular signal-regulated kinase (ERK) within 10 minutes and that the ERK inhibitor PD98059 blocked the inhibitory effect of IL-18. IL-18 also inhibited the production of collagen in systemic sclerosis (SSc) dermal fibroblasts. Our data indicate that IL-18 downregulates collagen production in HDF directly via Ets-1 and the ERK pathway, suggesting that IL-18 may exert antifibrotic activities in dermal fibroblasts. | - |
dc.format.extent | 10 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.title | IL-18 Downregulates Collagen Production in Human Dermal Fibroblasts via the ERK Pathway | - |
dc.type | Article | - |
dc.publisher.location | 미국 | - |
dc.identifier.doi | 10.1038/jid.2009.302 | - |
dc.identifier.scopusid | 2-s2.0-76649097312 | - |
dc.identifier.wosid | 000275017600014 | - |
dc.identifier.bibliographicCitation | JOURNAL OF INVESTIGATIVE DERMATOLOGY, v.130, no.3, pp 706 - 715 | - |
dc.citation.title | JOURNAL OF INVESTIGATIVE DERMATOLOGY | - |
dc.citation.volume | 130 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 706 | - |
dc.citation.endPage | 715 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Dermatology | - |
dc.relation.journalWebOfScienceCategory | Dermatology | - |
dc.subject.keywordPlus | GROWTH-FACTOR-BETA | - |
dc.subject.keywordPlus | TRANSCRIPTION FACTOR ETS-1 | - |
dc.subject.keywordPlus | MATRIX GENE-EXPRESSION | - |
dc.subject.keywordPlus | TGF-BETA | - |
dc.subject.keywordPlus | SYSTEMIC-SCLEROSIS | - |
dc.subject.keywordPlus | HEPATIC-FIBROSIS | - |
dc.subject.keywordPlus | LIVER FIBROSIS | - |
dc.subject.keywordPlus | ENDOTHELIAL-CELLS | - |
dc.subject.keywordPlus | SKIN FIBROBLASTS | - |
dc.subject.keywordPlus | INTERFERON-ALPHA | - |
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