ROR alpha Attenuates Wnt/beta-Catenin Signaling by PKC alpha-Dependent Phosphorylation in Colon Cancer
DC Field | Value | Language |
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dc.contributor.author | Lee, Ji Min | - |
dc.contributor.author | Kim, Ik Soo | - |
dc.contributor.author | Kim, Hyunkyung | - |
dc.contributor.author | Lee, Jason S. | - |
dc.contributor.author | Kim, Kyeongkyu | - |
dc.contributor.author | Yim, Hwa Young | - |
dc.contributor.author | Jeong, Jiyeong | - |
dc.contributor.author | Kim, Jung Hwa | - |
dc.contributor.author | Kim, Ji-Young | - |
dc.contributor.author | Lee, Hanna | - |
dc.contributor.author | Seo, Sang-Beom | - |
dc.contributor.author | Kim, Hogeun | - |
dc.contributor.author | Rosenfeld, Michael G. | - |
dc.contributor.author | Kim, Keun Il | - |
dc.contributor.author | Baek, Sung Hee | - |
dc.date.available | 2021-02-22T13:48:54Z | - |
dc.date.issued | 2010-01 | - |
dc.identifier.issn | 1097-2765 | - |
dc.identifier.issn | 1097-4164 | - |
dc.identifier.uri | https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/13286 | - |
dc.description.abstract | Wnt family members play diverse roles in development and disease. Noncanonical Wnt ligands can inhibit canonical Wnt signaling depending on the cellular context; however, the underlying mechanism of this antagonism remains poorly understood. Here we identify a specific mechanism of orphan nuclear receptor ROR alpha-mediated inhibition of canonical Wnt signaling in colon cancer. Wnt5a/PKC alpha-dependent phosphorylation on serine residue 35 of ROR alpha is crucial to link ROR alpha to Wnt/beta-catenin signaling, which exerts inhibitory function of the expression of Wnt/beta-catenin target genes. Intriguingly, there is a significant correlation of reduction of ROR alpha phosphorylation in colorectal tumor cases compared to their normal counterpart, providing the clinical relevance of the findings. Our data provide evidence for a role of ROR alpha, functioning at the crossroads between the canonical and the noncanonical Wnt signaling pathways, in mediating transrepression of the Wnt/beta-catenin target genes, thereby providing new approaches for the development of therapeutic agents for human cancers. | - |
dc.format.extent | 13 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | CELL PRESS | - |
dc.title | ROR alpha Attenuates Wnt/beta-Catenin Signaling by PKC alpha-Dependent Phosphorylation in Colon Cancer | - |
dc.type | Article | - |
dc.publisher.location | 미국 | - |
dc.identifier.doi | 10.1016/j.molcel.2009.12.022 | - |
dc.identifier.scopusid | 2-s2.0-74749106487 | - |
dc.identifier.wosid | 000274130600007 | - |
dc.identifier.bibliographicCitation | MOLECULAR CELL, v.37, no.2, pp 183 - 195 | - |
dc.citation.title | MOLECULAR CELL | - |
dc.citation.volume | 37 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 183 | - |
dc.citation.endPage | 195 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.subject.keywordPlus | BETA-CATENIN | - |
dc.subject.keywordPlus | AXIS FORMATION | - |
dc.subject.keywordPlus | PATHWAY | - |
dc.subject.keywordPlus | WNT-5A | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | GENE | - |
dc.subject.keywordAuthor | HUMDISEASE | - |
dc.subject.keywordAuthor | SIGNALING | - |
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