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ROR alpha Attenuates Wnt/beta-Catenin Signaling by PKC alpha-Dependent Phosphorylation in Colon Cancer

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dc.contributor.authorLee, Ji Min-
dc.contributor.authorKim, Ik Soo-
dc.contributor.authorKim, Hyunkyung-
dc.contributor.authorLee, Jason S.-
dc.contributor.authorKim, Kyeongkyu-
dc.contributor.authorYim, Hwa Young-
dc.contributor.authorJeong, Jiyeong-
dc.contributor.authorKim, Jung Hwa-
dc.contributor.authorKim, Ji-Young-
dc.contributor.authorLee, Hanna-
dc.contributor.authorSeo, Sang-Beom-
dc.contributor.authorKim, Hogeun-
dc.contributor.authorRosenfeld, Michael G.-
dc.contributor.authorKim, Keun Il-
dc.contributor.authorBaek, Sung Hee-
dc.date.available2021-02-22T13:48:54Z-
dc.date.issued2010-01-
dc.identifier.issn1097-2765-
dc.identifier.issn1097-4164-
dc.identifier.urihttps://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/13286-
dc.description.abstractWnt family members play diverse roles in development and disease. Noncanonical Wnt ligands can inhibit canonical Wnt signaling depending on the cellular context; however, the underlying mechanism of this antagonism remains poorly understood. Here we identify a specific mechanism of orphan nuclear receptor ROR alpha-mediated inhibition of canonical Wnt signaling in colon cancer. Wnt5a/PKC alpha-dependent phosphorylation on serine residue 35 of ROR alpha is crucial to link ROR alpha to Wnt/beta-catenin signaling, which exerts inhibitory function of the expression of Wnt/beta-catenin target genes. Intriguingly, there is a significant correlation of reduction of ROR alpha phosphorylation in colorectal tumor cases compared to their normal counterpart, providing the clinical relevance of the findings. Our data provide evidence for a role of ROR alpha, functioning at the crossroads between the canonical and the noncanonical Wnt signaling pathways, in mediating transrepression of the Wnt/beta-catenin target genes, thereby providing new approaches for the development of therapeutic agents for human cancers.-
dc.format.extent13-
dc.language영어-
dc.language.isoENG-
dc.publisherCELL PRESS-
dc.titleROR alpha Attenuates Wnt/beta-Catenin Signaling by PKC alpha-Dependent Phosphorylation in Colon Cancer-
dc.typeArticle-
dc.publisher.location미국-
dc.identifier.doi10.1016/j.molcel.2009.12.022-
dc.identifier.scopusid2-s2.0-74749106487-
dc.identifier.wosid000274130600007-
dc.identifier.bibliographicCitationMOLECULAR CELL, v.37, no.2, pp 183 - 195-
dc.citation.titleMOLECULAR CELL-
dc.citation.volume37-
dc.citation.number2-
dc.citation.startPage183-
dc.citation.endPage195-
dc.type.docTypeArticle-
dc.description.isOpenAccessN-
dc.description.journalRegisteredClasssci-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaBiochemistry & Molecular Biology-
dc.relation.journalResearchAreaCell Biology-
dc.relation.journalWebOfScienceCategoryBiochemistry & Molecular Biology-
dc.relation.journalWebOfScienceCategoryCell Biology-
dc.subject.keywordPlusBETA-CATENIN-
dc.subject.keywordPlusAXIS FORMATION-
dc.subject.keywordPlusPATHWAY-
dc.subject.keywordPlusWNT-5A-
dc.subject.keywordPlusCELLS-
dc.subject.keywordPlusGENE-
dc.subject.keywordAuthorHUMDISEASE-
dc.subject.keywordAuthorSIGNALING-
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