Ectopic Expression of Ephrin-A5 Under the EphA8 Promoter at the Anterior Region of the Superior Colliculus
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 노현아 | - |
dc.contributor.author | 박수철 | - |
dc.date.available | 2021-02-22T14:02:07Z | - |
dc.date.issued | 2010-06 | - |
dc.identifier.issn | 1226-2560 | - |
dc.identifier.issn | 2093-8144 | - |
dc.identifier.uri | https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/13502 | - |
dc.description.abstract | EphA/ephrin-A mediated signaling has emerged as a key mechanism regulating axon guidance and topographic mapping, particularly in the well-characterized visual system from the retina to the superior colliculus (SC). In this study, EphA8 bacterial artificial chromosome (BAC) was manipulated to contain a floxed eGFP and human ephrin-A5 expression cassette using homologous recombination method. In the mice containing the recombinant BAC, it was shown that GFP is expressed in an anterior>posterior gradient in the SC. Furthermore, when these mice were crossed with the transgenic mice expressing Cre under the EphA8 promoter, it was evident that a GFP expression cassette was eliminated, and that human ephrin-A5 was ectopically expressed in the anterior region of the SC. This transgenic model would be useful to analyze the role of ephrin-A5 in the SC during the retinocollicular topography formation. | - |
dc.format.extent | 5 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | 한국뇌신경과학회 | - |
dc.title | Ectopic Expression of Ephrin-A5 Under the EphA8 Promoter at the Anterior Region of the Superior Colliculus | - |
dc.type | Article | - |
dc.publisher.location | 대한민국 | - |
dc.identifier.doi | 10.5607/en.2010.19.1.49 | - |
dc.identifier.bibliographicCitation | Experimental Neurobiology, v.19, no.1, pp 49 - 53 | - |
dc.citation.title | Experimental Neurobiology | - |
dc.citation.volume | 19 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 49 | - |
dc.citation.endPage | 53 | - |
dc.identifier.kciid | ART001536635 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | kciCandi | - |
dc.subject.keywordAuthor | ephrin-A5 | - |
dc.subject.keywordAuthor | EphA8 | - |
dc.subject.keywordAuthor | superior colliculus | - |
dc.subject.keywordAuthor | topographic mapping | - |
dc.subject.keywordAuthor | ephrin-A5 | - |
dc.subject.keywordAuthor | EphA8 | - |
dc.subject.keywordAuthor | superior colliculus | - |
dc.subject.keywordAuthor | topographic mapping | - |
dc.identifier.url | https://www.en-journal.org/journal/view.html?uid=105&vmd=Full | - |
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