Anti-inflammatory, anti-angiogenic and anti-nociceptive activities of an ethanol extract of Salvia plebeia R. Brown
DC Field | Value | Language |
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dc.contributor.author | Jung, Hyun-Joo | - |
dc.contributor.author | Song, Yuri Seon | - |
dc.contributor.author | Lim, Chang-Jin | - |
dc.contributor.author | Park, Eun-Hee | - |
dc.date.available | 2021-02-22T14:15:55Z | - |
dc.date.issued | 2009-11-12 | - |
dc.identifier.issn | 0378-8741 | - |
dc.identifier.issn | 1872-7573 | - |
dc.identifier.uri | https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/13643 | - |
dc.description.abstract | Ethnopharmacological relevance: Salvia plebeia R. Brown has been used for the treatment of a variety of inflammatory diseases, cold and tumors in many countries, including Korea and China. Aim of the study: This study aimed to assess anti-inflammatory and related activities of an ethanol extract (SPEE) prepared from the dried whole parts of Salvia plebeia. Materials and methods: Anti-angiogenic and anti-nociceptive activities of SPEE were analyzed using the chick choriciallantoic membrane (CAM) assay and acetic acid-induced writhing response, respectively. Anti-inflammatory activity of SPEE was evaluated using acetic acid-induced vascular permeability, carrageenan-induced inflammation in the air pouch and analyses of nitrite content and induced nitric oxide synthase (iNOS) level in the macrophage cells. Results: SPEE gave rise to a significant inhibition in chick choriciallantoic membrane angiogenesis. SPEE exhibited anti-inflammatory activities in vascular permeability and air-pouch models. In the air-pouch model, SPEE was able to diminish exudate volume, number of polymorphonulcear leukocytes and nitrite content. SPEE also displayed anti-nociceptive activity in the writhing response model in mice. SPEE significantly decreased nitrite content and induced nitric oxide synthase (iNOS) in the lipopolysaccharide (LPS)-stimulated RAW264.7 macrophage cells, while it could not modulate cyclooxygenase-2 (COX-2) and matrix metalloproteinase-9 levels in the stimulated phages. SPEE decreased reactive oxygen species (ROS) level in the stimulated macrophages. Conclusion: The ethanol extract (SPEE) of Salvia plebeia possesses anti-inflammatory and related anti-angiogenic, anti-nociceptive and antioxidant activities, which offers partial support to its folkloric use. (C) 2009 Elsevier Ireland Ltd. All rights reserved. | - |
dc.format.extent | 6 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | ELSEVIER IRELAND LTD | - |
dc.title | Anti-inflammatory, anti-angiogenic and anti-nociceptive activities of an ethanol extract of Salvia plebeia R. Brown | - |
dc.type | Article | - |
dc.publisher.location | 아일랜드 | - |
dc.identifier.doi | 10.1016/j.jep.2009.08.031 | - |
dc.identifier.scopusid | 2-s2.0-70350344066 | - |
dc.identifier.wosid | 000272368000025 | - |
dc.identifier.bibliographicCitation | JOURNAL OF ETHNOPHARMACOLOGY, v.126, no.2, pp 355 - 360 | - |
dc.citation.title | JOURNAL OF ETHNOPHARMACOLOGY | - |
dc.citation.volume | 126 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 355 | - |
dc.citation.endPage | 360 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Plant Sciences | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalResearchArea | Integrative & Complementary Medicine | - |
dc.relation.journalWebOfScienceCategory | Plant Sciences | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
dc.relation.journalWebOfScienceCategory | Integrative & Complementary Medicine | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.subject.keywordPlus | ANTIOXIDANT ACTIVITY | - |
dc.subject.keywordPlus | R.BR. | - |
dc.subject.keywordAuthor | Salvia plebeia | - |
dc.subject.keywordAuthor | Angiogenesis | - |
dc.subject.keywordAuthor | Anti-angiogenic | - |
dc.subject.keywordAuthor | Anti-inflammatory | - |
dc.subject.keywordAuthor | Anti-nociceptive | - |
dc.subject.keywordAuthor | Chorioallantoic membrane | - |
dc.subject.keywordAuthor | Medicinal herb | - |
dc.subject.keywordAuthor | Reactive oxygen species | - |
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