p34(SEI-1) Inhibits Doxorubicin-Induced Senescence through a Pathway Mediated by Protein Kinase C-delta and c-Jun-NH2-Kinase 1 Activation in Human Breast Cancer MCF7 Cells
DC Field | Value | Language |
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dc.contributor.author | Lee, Sae Lo Oom | - |
dc.contributor.author | Hong, Seung-Woo | - |
dc.contributor.author | Shin, Jae-Sik | - |
dc.contributor.author | Kim, Jin Sun | - |
dc.contributor.author | Ko, Seong-Gyu | - |
dc.contributor.author | Hong, Nam-Joo | - |
dc.contributor.author | Kim, Dae Jin | - |
dc.contributor.author | Lee, Wang-Jae | - |
dc.contributor.author | Jin, Dong-Hoon | - |
dc.contributor.author | Lee, Myeong-Sok | - |
dc.date.available | 2021-02-22T14:16:01Z | - |
dc.date.issued | 2009-11 | - |
dc.identifier.issn | 1541-7786 | - |
dc.identifier.issn | 1557-3125 | - |
dc.identifier.uri | https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/13654 | - |
dc.description.abstract | In this study, we describe a novel function of the p34(SEI-1) protein, which is both an oncogenic protein and a positive regulator of the cell cycle. The p34(SEI-1) protein was found to inhibit doxorubicin-induced senescence. We investigated the molecular mechanisms of the inhibitory effect of p34(SEI-1) on senescence. First, we found that the activation of protein kinase C-delta (PKC-delta), which is cleaved into a 38 kDa active form from a 78 kDa pro-form, induced after doxorubicin treatment, was inhibited by p34(SEI-1). Furthermore, p34(SEI-1) induced the ubiquitination of PKC-delta. Yet, there is no interaction between p34(SEI-1) and PKC-delta. We also found that the phosphorylation of c-Jun-NH2-kinase 1 (JNK1) induced after doxorubicin treatment was suppressed by p34(SEI-1), but not in JNK2. Consistently, pharmacologic or genetic inactivation of either PKC-delta or JNK1 was found to inhibit doxorubicin-induced senescence. In addition, the genetic inactivation of PKC-delta by PKC-delta small interfering RNA resulted in an inhibition of JNK1 activation, but PKC-delta expression was not inactivated by JNK1 small interfering RNA, implying that the activation of JNK1 could be dependently induced by PKC-delta. Therefore, p34(SEI-1) inhibits senescence by inducing PKC-delta ubiquitination and preventing PKC-delta-dependent phosphorylation of JNK1. [Mol Cancer Res 2009;7(11):1845-53] | - |
dc.format.extent | 9 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | AMER ASSOC CANCER RESEARCH | - |
dc.title | p34(SEI-1) Inhibits Doxorubicin-Induced Senescence through a Pathway Mediated by Protein Kinase C-delta and c-Jun-NH2-Kinase 1 Activation in Human Breast Cancer MCF7 Cells | - |
dc.type | Article | - |
dc.publisher.location | 미국 | - |
dc.identifier.doi | 10.1158/1541-7786.MCR-09-0086 | - |
dc.identifier.scopusid | 2-s2.0-72449187632 | - |
dc.identifier.wosid | 000272006300010 | - |
dc.identifier.bibliographicCitation | MOLECULAR CANCER RESEARCH, v.7, no.11, pp 1845 - 1853 | - |
dc.citation.title | MOLECULAR CANCER RESEARCH | - |
dc.citation.volume | 7 | - |
dc.citation.number | 11 | - |
dc.citation.startPage | 1845 | - |
dc.citation.endPage | 1853 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Oncology | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.subject.keywordPlus | TERMINAL PROLIFERATION ARREST | - |
dc.subject.keywordPlus | HUMAN TUMOR-CELLS | - |
dc.subject.keywordPlus | REPLICATIVE SENESCENCE | - |
dc.subject.keywordPlus | PREMATURE SENESCENCE | - |
dc.subject.keywordPlus | HUMAN-FIBROBLASTS | - |
dc.subject.keywordPlus | FUNCTIONAL P53 | - |
dc.subject.keywordPlus | OVARIAN-CANCER | - |
dc.subject.keywordPlus | GROWTH ARREST | - |
dc.subject.keywordPlus | ONCOGENIC RAS | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.identifier.url | https://mcr.aacrjournals.org/content/7/11/1845 | - |
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