Bone morphogenetic protein-4 induced by NDRG2 expression inhibits MMP-9 activity in breast cancer cells
DC Field | Value | Language |
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dc.contributor.author | Shon, Soo-Kyung | - |
dc.contributor.author | Kim, Aeyung | - |
dc.contributor.author | Kim, Ji Young | - |
dc.contributor.author | Kim, Keun Il | - |
dc.contributor.author | Yang, Young | - |
dc.contributor.author | Lim, Jong-Seok | - |
dc.date.available | 2021-02-22T14:16:48Z | - |
dc.date.issued | 2009-07 | - |
dc.identifier.issn | 0006-291X | - |
dc.identifier.issn | 1090-2104 | - |
dc.identifier.uri | https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/13718 | - |
dc.description.abstract | In the current study, we examined the function of N-myc downstream-regulated gene 2 (NDRG2) expression in breast cancer cells, especially focusing on the role of bone morphogenetic protein-4 (BMP-4) induced by NDRG2. NDRG2 expression in MDA-MB-231 cells inhibited the mRNA expression of several matrix metalloproteinases (MMPs) and the gelatinolytic activity of MMP-9. Interestingly, a specific induction of active BMP-4 was exclusively observed in MDA-MB-231-NDRG2 cells but not in MDA-MB-231-mock cells. Neutralization of BMP-4 in MDA-MB-231-NDRG2 cells resulted in the rescue of MMP-9 mRNA expression and migration capacity. In addition, treatment with recombinant BMP-4 dramatically suppressed MMP-9 mRNA expression, gelatinolytic MMP-9 activity, migration, and invasion capacity both in MDA-MB-231 and PMA-treated MCF-7 cells. Collectively, our data show that BMP-4 induced by NDRG2 expression inhibits the metastatic potential of breast cancer cells, especially via suppression of MMP-9 activity. (C) 2009 Elsevier Inc. All rights reserved | - |
dc.format.extent | 6 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | ACADEMIC PRESS INC ELSEVIER SCIENCE | - |
dc.title | Bone morphogenetic protein-4 induced by NDRG2 expression inhibits MMP-9 activity in breast cancer cells | - |
dc.type | Article | - |
dc.publisher.location | 미국 | - |
dc.identifier.doi | 10.1016/j.bbrc.2009.05.038 | - |
dc.identifier.scopusid | 2-s2.0-67349212840 | - |
dc.identifier.wosid | 000267037300014 | - |
dc.identifier.bibliographicCitation | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.385, no.2, pp 198 - 203 | - |
dc.citation.title | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.citation.volume | 385 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 198 | - |
dc.citation.endPage | 203 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Biophysics | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biophysics | - |
dc.subject.keywordPlus | CARCINOMA-CELLS | - |
dc.subject.keywordPlus | PROLIFERATION | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | ANGIOGENESIS | - |
dc.subject.keywordPlus | SUPPRESSOR | - |
dc.subject.keywordPlus | APOPTOSIS | - |
dc.subject.keywordPlus | SURVIVAL | - |
dc.subject.keywordPlus | INVASION | - |
dc.subject.keywordPlus | FAMILY | - |
dc.subject.keywordPlus | GROWTH | - |
dc.subject.keywordAuthor | Breast cancer | - |
dc.subject.keywordAuthor | NDRG2 | - |
dc.subject.keywordAuthor | BMP-4 | - |
dc.subject.keywordAuthor | MMP | - |
dc.subject.keywordAuthor | Migration | - |
dc.subject.keywordAuthor | Invasion | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/abs/pii/S0006291X09009590?via%3Dihub | - |
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