alpha-Synuclein induces migration of BV-2 microglial cells by up-regulation of CD44 and MT1-MMP
DC Field | Value | Language |
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dc.contributor.author | Kim, Seonghan | - |
dc.contributor.author | Cho, Seo-Hyun | - |
dc.contributor.author | Kim, Ka Young | - |
dc.contributor.author | Shin, Ki Young | - |
dc.contributor.author | Kim, Hye-Sun | - |
dc.contributor.author | Park, Cheol-Hyoung | - |
dc.contributor.author | Chang, Keun-A | - |
dc.contributor.author | Lee, Sang Hyung | - |
dc.contributor.author | Cho, Daeho | - |
dc.contributor.author | Suh, Yoo-Hun | - |
dc.date.available | 2021-02-22T14:17:08Z | - |
dc.date.issued | 2009-06 | - |
dc.identifier.issn | 0022-3042 | - |
dc.identifier.issn | 1471-4159 | - |
dc.identifier.uri | https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/13747 | - |
dc.description.abstract | Although there is known to be a marked concentration of reactive microglia in the substantia nigra pars compacta (SNpc) of patients with Parkinson's disease (PD), a disorder in which alpha-synuclein plays a key pathogenic role, the specific roles of alpha-synuclein and microglia remains poorly understood. In this study, we investigated the effects of alpha-synuclein and the mechanisms of invasive microglial migration into the SNpc. We show that alpha-synuclein up-regulates the expressions of the cell adhesion molecule CD44 and the cell surface protease membrane-type 1 matrix metalloproteinase through the extracellular regulated kinases 1/2 pathway. These concurrent inductions increased the generation of soluble CD44 to liberate microglia from the surrounding extracellular matrix for migration. The effects of alpha-synuclein were identical in BV-2 murine microglial cells subjected to cDNA transfection and extracellular treatment. These inductions in primary microglial cultures of C57Bl/6 mice were identical to those in BV-2 cells. alpha-Synuclein-induced microglial migration into the SNpc was confirmed in vivo using a 6-hydroxydopamine mouse model of PD. Our data demonstrate a correlation between alpha-synuclein-induced phenotypic changes and microglial migration. With the recruitment of the microglial population into the SNpc during dopaminergic neurodegeneration, alpha-synuclein may play a role in accelerating the pathogenesis of PD. | - |
dc.format.extent | 14 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | WILEY | - |
dc.title | alpha-Synuclein induces migration of BV-2 microglial cells by up-regulation of CD44 and MT1-MMP | - |
dc.type | Article | - |
dc.publisher.location | 미국 | - |
dc.identifier.doi | 10.1111/j.1471-4159.2009.06075.x | - |
dc.identifier.scopusid | 2-s2.0-65549122553 | - |
dc.identifier.wosid | 000265935200025 | - |
dc.identifier.bibliographicCitation | JOURNAL OF NEUROCHEMISTRY, v.109, no.5, pp 1483 - 1496 | - |
dc.citation.title | JOURNAL OF NEUROCHEMISTRY | - |
dc.citation.volume | 109 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 1483 | - |
dc.citation.endPage | 1496 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Neurosciences | - |
dc.subject.keywordPlus | MEMBRANE-TYPE-1 MATRIX-METALLOPROTEINASE | - |
dc.subject.keywordPlus | PARKINSONS-DISEASE | - |
dc.subject.keywordPlus | SOLUBLE CD44 | - |
dc.subject.keywordPlus | ACTIVATES MICROGLIA | - |
dc.subject.keywordPlus | COLORECTAL-CANCER | - |
dc.subject.keywordPlus | MELANOMA-CELLS | - |
dc.subject.keywordPlus | BRAIN | - |
dc.subject.keywordPlus | NEURODEGENERATION | - |
dc.subject.keywordPlus | INFLAMMATION | - |
dc.subject.keywordPlus | MECHANISMS | - |
dc.subject.keywordAuthor | alpha-synuclein | - |
dc.subject.keywordAuthor | CD44 | - |
dc.subject.keywordAuthor | membrane-type 1 matrix metalloproteinase | - |
dc.subject.keywordAuthor | microglia | - |
dc.subject.keywordAuthor | migration | - |
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