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Chitosan hydrogel containing GMCSF and a cancer drug exerts synergistic anti-tumor effects via the induction of CD8(+) T cell-mediated anti-tumor immunity

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dc.contributor.authorSeo, Soo Hong-
dc.contributor.authorHan, Hee Dong-
dc.contributor.authorNoh, Kyung Hee-
dc.contributor.authorKim, Tae Woo-
dc.contributor.authorSon, Sang Wook-
dc.date.available2021-02-22T14:18:04Z-
dc.date.created2020-09-01-
dc.date.issued2009-03-
dc.identifier.issn0262-0898-
dc.identifier.urihttps://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/13815-
dc.description.abstractCancer treatments consisting of a combination of chemotherapy and immunotherapy have been vigorously exploited to further improve the efficacy of cancer therapies. In this study, we utilized a chitosan hydrogel (CH) system loaded with GMCSF and a cancer drug as a chemo-immunotherapeutic agent in an effort to assess the effects on tumor growth in mice using TC-1 cervical tumor cells, which express the tumor-specific antigen, HPV-16 E7. The growth of TC-1 tumors was significantly reduced in mice treated with a CH harboring a cancer drug (doxorubicin (DOX), cisplatin (CDDP), or cyclophosphamide (CTX)) and GMCSF (CH-a cancer drug + GMCSF), as compared to other groups that were treated with CH containing only a cancer drug(CH-a cancer drug) or GMCSF(CH-GMCSF). Among the cancer drugs, CTX exerted the most potent anti-tumor effects. Interestingly, the intra-tumoral injection of CH-a cancer drug + GMCSF induced a significant E7-specific CD8(+) T cell immune response as compared to CH-GMCSF or CH-a cancer drug. This enhancement of tumor antigen-specific CD8(+) T cell immunity was associated principally with the anti-tumor effects induced by CH-CTX + GMCSF, as demonstrated by antibody depletion. Collectively, the aforementioned results indicate that co-treatment of tumors with a combination of GMCSF and a cancer drug incorporated into a CH system results in synergistic anti-tumor effects, which occur via the induction of a tumor antigen-specific CD8(+) T cell-mediated anti-tumor immunity. This study demonstrates the use of a biodegradable hydrogel system for the co-delivery of an immunoadjuvant and an anti-cancer drug for successful chemo-immunotherapy.-
dc.language영어-
dc.language.isoen-
dc.publisherSPRINGER-
dc.subjectCOLONY-STIMULATING FACTOR-
dc.subjectDNA VACCINE POTENCY-
dc.subjectTUMOR-ANTIGEN GENE-
dc.subjectIN-VIVO-
dc.subjectDENDRITIC CELLS-
dc.subjectSUSTAINED-RELEASE-
dc.subjectDELIVERY SYSTEM-
dc.subjectGM-CSF-
dc.subjectBIOMEDICAL APPLICATIONS-
dc.subjectCROSS-PRESENTATION-
dc.titleChitosan hydrogel containing GMCSF and a cancer drug exerts synergistic anti-tumor effects via the induction of CD8(+) T cell-mediated anti-tumor immunity-
dc.typeArticle-
dc.contributor.affiliatedAuthorKim, Tae Woo-
dc.identifier.doi10.1007/s10585-008-9228-5-
dc.identifier.scopusid2-s2.0-61449120967-
dc.identifier.wosid000263788500002-
dc.identifier.bibliographicCitationCLINICAL & EXPERIMENTAL METASTASIS, v.26, no.3, pp.179 - 187-
dc.relation.isPartOfCLINICAL & EXPERIMENTAL METASTASIS-
dc.citation.titleCLINICAL & EXPERIMENTAL METASTASIS-
dc.citation.volume26-
dc.citation.number3-
dc.citation.startPage179-
dc.citation.endPage187-
dc.type.rimsART-
dc.type.docTypeArticle-
dc.description.journalClass1-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaOncology-
dc.relation.journalWebOfScienceCategoryOncology-
dc.subject.keywordPlusCOLONY-STIMULATING FACTOR-
dc.subject.keywordPlusDNA VACCINE POTENCY-
dc.subject.keywordPlusTUMOR-ANTIGEN GENE-
dc.subject.keywordPlusIN-VIVO-
dc.subject.keywordPlusDENDRITIC CELLS-
dc.subject.keywordPlusSUSTAINED-RELEASE-
dc.subject.keywordPlusDELIVERY SYSTEM-
dc.subject.keywordPlusGM-CSF-
dc.subject.keywordPlusBIOMEDICAL APPLICATIONS-
dc.subject.keywordPlusCROSS-PRESENTATION-
dc.subject.keywordAuthorHydrogel-
dc.subject.keywordAuthorGMCSF-
dc.subject.keywordAuthorCancer drugs-
dc.subject.keywordAuthorChemo-immunotherapy-
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