In vitro anti-inflammatory activity of lignans isolated from Magnolia fargesii
DC Field | Value | Language |
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dc.contributor.author | Kim, Jae Yeon | - |
dc.contributor.author | Lim, Hyo Jin | - |
dc.contributor.author | Lee, Da Yeon | - |
dc.contributor.author | Kim, Ji Sun | - |
dc.contributor.author | Kim, Do Hee | - |
dc.contributor.author | Lee, Hwa Jin | - |
dc.contributor.author | Kim, Hee Doo | - |
dc.contributor.author | Jeon, Raok | - |
dc.contributor.author | Ryu, Jae-Ha | - |
dc.date.available | 2021-02-22T14:18:12Z | - |
dc.date.issued | 2009-02-01 | - |
dc.identifier.issn | 0960-894X | - |
dc.identifier.issn | 1464-3405 | - |
dc.identifier.uri | https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/13825 | - |
dc.description.abstract | The overproduction of nitric oxide (NO) and prostaglandin E-2 (PGE(2)) causes neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. Four lignans, (+)-eudesmin (1), (+)-magnolin (2), (+)yangambin (3) and a new structure named as epimagnolin B (4) were isolated from Magnolia fargesii (Magnoliaceae) as the inhibitors of NO production in LPS-activated microglia. The most potent compound 4 inhibited the production of NO and PGE(2) and the expression of respective enzyme iNOS and COX-2 through the suppression of I-kappa B-alpha degradation and nuclear translocation of p65 subunit of NF-kappa B. (C) 2009 Published by Elsevier Ltd. | - |
dc.format.extent | 4 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | PERGAMON-ELSEVIER SCIENCE LTD | - |
dc.title | In vitro anti-inflammatory activity of lignans isolated from Magnolia fargesii | - |
dc.type | Article | - |
dc.publisher.location | 영국 | - |
dc.identifier.doi | 10.1016/j.bmcl.2008.11.103 | - |
dc.identifier.scopusid | 2-s2.0-58549094899 | - |
dc.identifier.wosid | 000262707000084 | - |
dc.identifier.bibliographicCitation | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v.19, no.3, pp 937 - 940 | - |
dc.citation.title | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | - |
dc.citation.volume | 19 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 937 | - |
dc.citation.endPage | 940 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Organic | - |
dc.subject.keywordPlus | NITRIC-OXIDE SYNTHASES | - |
dc.subject.keywordPlus | FLOWER BUDS | - |
dc.subject.keywordPlus | SELECTIVE INHIBITOR | - |
dc.subject.keywordPlus | FLOS-MAGNOLIAE | - |
dc.subject.keywordPlus | LIPOPOLYSACCHARIDE | - |
dc.subject.keywordPlus | STEREOCHEMISTRY | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | CYCLOOXYGENASE-2 | - |
dc.subject.keywordPlus | DERIVATIVES | - |
dc.subject.keywordPlus | ASSIGNMENT | - |
dc.subject.keywordAuthor | Magnolia fargesii | - |
dc.subject.keywordAuthor | Nitric oxide | - |
dc.subject.keywordAuthor | Prostaglandin E-2 | - |
dc.subject.keywordAuthor | Microglia | - |
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