Dexamethasone에 의한 RANKL 유도성 파골세포 분화 촉진 효과
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 노아롱새미 | - |
dc.contributor.author | 박효정 | - |
dc.contributor.author | 이정민 | - |
dc.contributor.author | 천링 | - |
dc.contributor.author | 양미혜 | - |
dc.contributor.author | 임미정 | - |
dc.date.available | 2021-02-22T14:31:30Z | - |
dc.date.issued | 2009-04 | - |
dc.identifier.issn | 0377-9556 | - |
dc.identifier.uri | https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/14025 | - |
dc.description.abstract | We explored the effects of dexamethasone on osteoclast precursors using BMMs. Dexamethasone inhibited the proliferation of BMMs. Furthermore, it stimulated the osteoclast formation via NFATc1 activation in the presence of RANKL. Since dexamethasone targeted the early stage of osteoclast formation, we investigated its effect on mRNA expression of GR and IFN-β. Whereas dexamethasone had no effects on GR expression in the presence of RANKL, it reduced the expression of IFN-β, suggesting that dexamethasone increased RANKL-induced osteoclast formation by modulating IFN-β. | - |
dc.format.extent | 5 | - |
dc.language | 한국어 | - |
dc.language.iso | KOR | - |
dc.publisher | 대한약학회 | - |
dc.title | Dexamethasone에 의한 RANKL 유도성 파골세포 분화 촉진 효과 | - |
dc.title.alternative | The Stimulatory Effect of Dexamethasone on RANKL-induced Osteoclastogenesis | - |
dc.type | Article | - |
dc.publisher.location | South Korea | - |
dc.identifier.bibliographicCitation | 약 학 회 지, v.53, no.2, pp 78 - 82 | - |
dc.citation.title | 약 학 회 지 | - |
dc.citation.volume | 53 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 78 | - |
dc.citation.endPage | 82 | - |
dc.identifier.kciid | ART001337234 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | kci | - |
dc.subject.keywordAuthor | glucocorticoid | - |
dc.subject.keywordAuthor | dexamethasone | - |
dc.subject.keywordAuthor | osteoclast | - |
dc.subject.keywordAuthor | IFN-β | - |
dc.identifier.url | http://scholar.dkyobobook.co.kr/searchDetail.laf?barcode=4010024049176 | - |
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