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Synthesis of azaisoflavones and their inhibitory activities of NO production in activated microglia
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| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Jin, Guo Hua | - |
| dc.contributor.author | Ha, Sang Keun | - |
| dc.contributor.author | Park, Hye Min | - |
| dc.contributor.author | Kang, Bomi | - |
| dc.contributor.author | Kim, Sun Yeou | - |
| dc.contributor.author | Kim, Hee-Do | - |
| dc.contributor.author | Ryu, Jae-Ha | - |
| dc.contributor.author | Jeon, Raok | - |
| dc.date.available | 2021-02-22T14:33:26Z | - |
| dc.date.issued | 2008-07-15 | - |
| dc.identifier.issn | 0960-894X | - |
| dc.identifier.issn | 1464-3405 | - |
| dc.identifier.uri | https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/14223 | - |
| dc.description.abstract | A series of azaisoflavones were synthesized and their biological activities were evaluated for nitric oxide (NO) production and inducible NO synthase (iNOS) expression in BV-2 microglia cell lines. Among these compounds, compound 8d was the most potent with IC(50) 7.83 mu M for inhibition of NO production. Also, compound 8d inhibited expression of iNOS in LPS-induced BV2 cells. This result suggests that compound 8d inhibited the production of NO by suppressing the expression of iNOS. (c) 2008 Elsevier Ltd. All rights reserved. | - |
| dc.format.extent | 3 | - |
| dc.language | 영어 | - |
| dc.language.iso | ENG | - |
| dc.publisher | PERGAMON-ELSEVIER SCIENCE LTD | - |
| dc.title | Synthesis of azaisoflavones and their inhibitory activities of NO production in activated microglia | - |
| dc.type | Article | - |
| dc.publisher.location | 영국 | - |
| dc.identifier.doi | 10.1016/j.bmcl.2008.05.106 | - |
| dc.identifier.scopusid | 2-s2.0-47149085965 | - |
| dc.identifier.wosid | 000257640400059 | - |
| dc.identifier.bibliographicCitation | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v.18, no.14, pp 4092 - 4094 | - |
| dc.citation.title | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | - |
| dc.citation.volume | 18 | - |
| dc.citation.number | 14 | - |
| dc.citation.startPage | 4092 | - |
| dc.citation.endPage | 4094 | - |
| dc.type.docType | Article | - |
| dc.description.isOpenAccess | N | - |
| dc.description.journalRegisteredClass | scie | - |
| dc.description.journalRegisteredClass | scopus | - |
| dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
| dc.relation.journalResearchArea | Chemistry | - |
| dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
| dc.relation.journalWebOfScienceCategory | Chemistry, Organic | - |
| dc.subject.keywordPlus | PROTECTS DOPAMINERGIC-NEURONS | - |
| dc.subject.keywordPlus | PARKINSONS-DISEASE | - |
| dc.subject.keywordPlus | INFLAMMATION | - |
| dc.subject.keywordPlus | MECHANISMS | - |
| dc.subject.keywordPlus | GENISTEIN | - |
| dc.subject.keywordPlus | CELLS | - |
| dc.subject.keywordPlus | SYSTEMS | - |
| dc.subject.keywordPlus | IMMUNE | - |
| dc.subject.keywordAuthor | azaisoflavone | - |
| dc.subject.keywordAuthor | nitric oxide | - |
| dc.subject.keywordAuthor | iNOS | - |
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