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Inhibition of lipopolysaccharide-induced inducible nitric oxide synthase and cyclooxygenase-2 expression by xanthanolides isolated from Xanthium strumarium

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dc.contributor.authorYoon, Jeong Hoon-
dc.contributor.authorLim, Hyo Jin-
dc.contributor.authorLee, Hwa Jin-
dc.contributor.authorKim, Hee-Doo-
dc.contributor.authorJeon, Raok-
dc.contributor.authorRyu, Jae-Ha-
dc.date.available2021-02-22T14:46:33Z-
dc.date.issued2008-03-15-
dc.identifier.issn0960-894X-
dc.identifier.issn1464-3405-
dc.identifier.urihttps://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/14298-
dc.description.abstractThree sesquiterpenoids, xanthatin (1), xanthinosin (2), and 4-oxo-bedfordia acid (3) were isolated from Xanthium strumarium as inhibitors of nitric oxide synthesis in activated microglia (IC50 values: 0.47, 11.2, 136.5 mu M, respectively). Compounds 1 and 2 suppressed the expression of iNOS and COX-2 and the activity of NF-kappa B through the inhibition of LPS-induced I-kappa B-alpha degradation in microglia. (C) 2008 Elsevier Ltd. All rights reserved.-
dc.format.extent4-
dc.language영어-
dc.language.isoENG-
dc.publisherPERGAMON-ELSEVIER SCIENCE LTD-
dc.titleInhibition of lipopolysaccharide-induced inducible nitric oxide synthase and cyclooxygenase-2 expression by xanthanolides isolated from Xanthium strumarium-
dc.typeArticle-
dc.publisher.location영국-
dc.identifier.doi10.1016/j.bmcl.2007.12.076-
dc.identifier.scopusid2-s2.0-40749141540-
dc.identifier.wosid000254180300079-
dc.identifier.bibliographicCitationBIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v.18, no.6, pp 2179 - 2182-
dc.citation.titleBIOORGANIC & MEDICINAL CHEMISTRY LETTERS-
dc.citation.volume18-
dc.citation.number6-
dc.citation.startPage2179-
dc.citation.endPage2182-
dc.type.docTypeArticle-
dc.description.isOpenAccessN-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaPharmacology & Pharmacy-
dc.relation.journalResearchAreaChemistry-
dc.relation.journalWebOfScienceCategoryChemistry, Medicinal-
dc.relation.journalWebOfScienceCategoryChemistry, Organic-
dc.subject.keywordPlusRAW 264.7 MACROPHAGES-
dc.subject.keywordPlusINFLAMMATORY RESPONSE-
dc.subject.keywordPlusINTERFERON-GAMMA-
dc.subject.keywordPlusNERVOUS-SYSTEM-
dc.subject.keywordPlusBIOSYNTHESIS-
dc.subject.keywordPlusDISEASES-
dc.subject.keywordPlusBRAIN-
dc.subject.keywordPlusSTRATEGIES-
dc.subject.keywordPlusMICROGLIA-
dc.subject.keywordPlusINJURY-
dc.subject.keywordAuthornitric oxide synthase-
dc.subject.keywordAuthorcyclooxygenase-
dc.subject.keywordAuthorXanthium strumarium-
dc.subject.keywordAuthorsesquiterpene-
dc.subject.keywordAuthornuclear factor kappa B-
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