Increased expression of the F1F0 ATP synthase in response to iron in heart mitochondria
DC Field | Value | Language |
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dc.contributor.author | Kim, Misun | - |
dc.contributor.author | Kim, Jinsun | - |
dc.contributor.author | Cheon, Choong-Ill | - |
dc.contributor.author | Cho, Dae Ho | - |
dc.contributor.author | Park, Jong Hoon | - |
dc.contributor.author | Kim, Keun Il | - |
dc.contributor.author | Lee, Kyo-Young | - |
dc.contributor.author | Song, Eunsook | - |
dc.date.available | 2021-02-22T14:46:48Z | - |
dc.date.issued | 2008-02 | - |
dc.identifier.issn | 1976-6696 | - |
dc.identifier.issn | 1976-670X | - |
dc.identifier.uri | https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/14318 | - |
dc.description.abstract | The objective of the present study was to identify mitochondrial components associated with the damage caused by iron to the rat heart. Decreased cell viability was assessed by increased presence of lactate dehydrogenase (LDH) in serum. To assess the functional integrity of mitochondria, Reactive Oxygen Species (ROS), the Respiratory Control Ratio (RCR), ATP and chelatable iron content were measured in the heart. Chelatable iron increased 15-fold in the mitochondria and ROS increased by 59%. Deterioration of mitochondrial function in the presence of iron was demonstrated by low RCR (46% decrease) and low ATP content (96% decrease). Using two dimensional gel electrophoresis (2DE), we identified alterations in 21 mitochondrial proteins triggered by iron overload. Significantly, expression of the a, beta, and d subunits of F1F0 ATP synthase increased along with the loss of ATP. This suggests that the F1F0 ATP synthase participates in iron metabolism. | - |
dc.format.extent | 5 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | KOREAN SOCIETY BIOCHEMISTRY & MOLECULAR BIOLOGY | - |
dc.title | Increased expression of the F1F0 ATP synthase in response to iron in heart mitochondria | - |
dc.type | Article | - |
dc.publisher.location | 대한민국 | - |
dc.identifier.doi | 10.5483/BMBRep.2008.41.2.153 | - |
dc.identifier.scopusid | 2-s2.0-40549117465 | - |
dc.identifier.wosid | 000255359500010 | - |
dc.identifier.bibliographicCitation | BMB REPORTS, v.41, no.2, pp 153 - 157 | - |
dc.citation.title | BMB REPORTS | - |
dc.citation.volume | 41 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 153 | - |
dc.citation.endPage | 157 | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART001246480 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.subject.keywordPlus | OXIDATIVE-PHOSPHORYLATION | - |
dc.subject.keywordPlus | PROTEOMIC ANALYSIS | - |
dc.subject.keywordPlus | RAT-HEART | - |
dc.subject.keywordPlus | PROTEINS | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | OVERLOAD | - |
dc.subject.keywordPlus | INJURY | - |
dc.subject.keywordPlus | MUTATION | - |
dc.subject.keywordPlus | SULFUR | - |
dc.subject.keywordPlus | TARGET | - |
dc.subject.keywordAuthor | F1F0 ATP synthase | - |
dc.subject.keywordAuthor | heart mitochondria | - |
dc.subject.keywordAuthor | iron overload | - |
dc.subject.keywordAuthor | proteomics | - |
dc.identifier.url | http://koreascience.or.kr/article/JAKO200809137570053.page | - |
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