Clusterin, a novel modulator of TGF-beta signaling, is involved in Smad2/3 stability
DC Field | Value | Language |
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dc.contributor.author | Lee, Kwan-Bok | - |
dc.contributor.author | Jeon, Jun-Ho | - |
dc.contributor.author | Choi, Inpyo | - |
dc.contributor.author | Kwon, O-Yu | - |
dc.contributor.author | Yu, Kweon | - |
dc.contributor.author | You, Kwan-Hee | - |
dc.date.available | 2021-02-22T14:46:53Z | - |
dc.date.issued | 2008-02-22 | - |
dc.identifier.issn | 0006-291X | - |
dc.identifier.issn | 1090-2104 | - |
dc.identifier.uri | https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/14322 | - |
dc.description.abstract | Clusterin (CLU) is known as a multifunctional protein involved in a variety of physiological processes including lipid transport, epithelial cell differentiation, tumorigenesis, and apoptosis. It is known that CLU interacts with TGF-beta type 11 receptor (T beta R11). However, the relationship of CLU and TGF-beta signaling is unclear. Here we present that CLU is a novel modulator of TGF-beta signaling by regulating Smad2/3 proteins. Overexpression of CLU enhanced TGF-beta-induced transcriptional activity and increased the amount of Smad2/3 proteins, while CLU siRNA repressed TGF-beta-induced transcriptional activity and decreased the amount of Smad2/3 proteins in Hep3B cells. We also found that CLU was involved in Smad2/3 stability at the protein level. These findings suggest that CLU regulates TGF-beta signaling pathway by modulating the stability of Smad2/3 proteins. (c) 2007 Elsevier Inc. All rights reserved. | - |
dc.format.extent | 5 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | ACADEMIC PRESS INC ELSEVIER SCIENCE | - |
dc.title | Clusterin, a novel modulator of TGF-beta signaling, is involved in Smad2/3 stability | - |
dc.type | Article | - |
dc.publisher.location | 미국 | - |
dc.identifier.doi | 10.1016/j.bbrc.2007.12.033 | - |
dc.identifier.scopusid | 2-s2.0-37549041733 | - |
dc.identifier.wosid | 000252512800007 | - |
dc.identifier.bibliographicCitation | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.366, no.4, pp 905 - 909 | - |
dc.citation.title | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.citation.volume | 366 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 905 | - |
dc.citation.endPage | 909 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Biophysics | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biophysics | - |
dc.subject.keywordPlus | I-KAPPA-B | - |
dc.subject.keywordPlus | UBIQUITIN-DEPENDENT DEGRADATION | - |
dc.subject.keywordPlus | PROTEINS | - |
dc.subject.keywordPlus | CHAPERONE | - |
dc.subject.keywordPlus | TRANSCRIPTION | - |
dc.subject.keywordPlus | HOMOLOG | - |
dc.subject.keywordPlus | COMPLEX | - |
dc.subject.keywordPlus | STRESS | - |
dc.subject.keywordPlus | ALPHA | - |
dc.subject.keywordPlus | DEATH | - |
dc.subject.keywordAuthor | clusterin | - |
dc.subject.keywordAuthor | TGF-beta | - |
dc.subject.keywordAuthor | Smad2 | - |
dc.subject.keywordAuthor | Smad3 | - |
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