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In vitro anti-inflammatory activity of 3-O-methyl-flavones isolated from Siegesbeckia glabrescens

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dc.contributor.authorKim, Jae Yeon-
dc.contributor.authorLim, Hyo Jin-
dc.contributor.authorRyu, Jae-Ha-
dc.date.available2021-02-22T14:46:54Z-
dc.date.issued2008-02-15-
dc.identifier.issn0960-894X-
dc.identifier.issn1464-3405-
dc.identifier.urihttps://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/14324-
dc.description.abstractFour flavones, 3,4'- O- dimethylquercetin (1), 3,7- O- dimethylquercetin (2), 3- O- methylquercetin (3) and 3,7,4'- O- trimethylquercetin (4) were isolated as the inhibitors of nitric oxide production in activated microglia (IC50 values: 11.1, 4.2, 3.8, and 25.1 mu M, respectively). They suppressed the expression of protein and mRNA of inducible nitric oxide synthase. Furthermore, compounds 2 and 3 showed scavenging activity of peroxynitrite with SC50 values of 1.75 and 0.77 mu M, respectively. (C) 2007 Elsevier Ltd. All rights reserved.-
dc.format.extent4-
dc.language영어-
dc.language.isoENG-
dc.publisherPERGAMON-ELSEVIER SCIENCE LTD-
dc.titleIn vitro anti-inflammatory activity of 3-O-methyl-flavones isolated from Siegesbeckia glabrescens-
dc.typeArticle-
dc.publisher.location영국-
dc.identifier.doi10.1016/j.bmcl.2007.12.052-
dc.identifier.scopusid2-s2.0-38949095683-
dc.identifier.wosid000254180000051-
dc.identifier.bibliographicCitationBIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v.18, no.4, pp 1511 - 1514-
dc.citation.titleBIOORGANIC & MEDICINAL CHEMISTRY LETTERS-
dc.citation.volume18-
dc.citation.number4-
dc.citation.startPage1511-
dc.citation.endPage1514-
dc.type.docTypeArticle-
dc.description.isOpenAccessN-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaPharmacology & Pharmacy-
dc.relation.journalResearchAreaChemistry-
dc.relation.journalWebOfScienceCategoryChemistry, Medicinal-
dc.relation.journalWebOfScienceCategoryChemistry, Organic-
dc.subject.keywordPlusNITRIC-OXIDE PRODUCTION-
dc.subject.keywordPlusINFLAMMATORY RESPONSE-
dc.subject.keywordPlusCELLS-
dc.subject.keywordPlusLIPOPOLYSACCHARIDE-
dc.subject.keywordPlusPEROXYNITRITE-
dc.subject.keywordPlusAPOPTOSIS-
dc.subject.keywordPlusMICROGLIA-
dc.subject.keywordPlusDISEASES-
dc.subject.keywordPlusSYSTEM-
dc.subject.keywordPlusNO-
dc.subject.keywordAuthorSiegesbeckia glabrescens-
dc.subject.keywordAuthornitric oxide synthase-
dc.subject.keywordAuthorperoxynitrite-
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