The Regulation of Taurine Transport through the Blood-Placental Barrier under Oxidative Stress
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 강영숙 | - |
dc.contributor.author | Yoo-Geum Yoon | - |
dc.date.available | 2021-02-22T14:47:15Z | - |
dc.date.issued | 2008-10 | - |
dc.identifier.issn | 2093-5552 | - |
dc.identifier.issn | 2093-6214 | - |
dc.identifier.uri | https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/14361 | - |
dc.description.abstract | In the present study, we examined the changes of uptake and efflux of taurine under various conditions inducing oxidative stress using rat conditionally immortalized syncytiotrophoblast cell line, TR-TBT cell, as blood-placental barrier in vitro model. In addition, we identified the characteristics of taurine transport in TR-TBT cells including general features, besides effect of calcium ion on taurine transport. Taurine uptake showed time, Na+ and Cl− dependency, and was decreased by PKC activator in TR-TBT cells. Also, calcium free condition decreased taurine uptake and evoked taurine efflux in the cells. Oxidative stress induced the change of taurine transport in TR-TBT cells, but the changes were different depending on the types of stimulation inducing oxidative stress. The taurine uptake was increased by TNF-α, LPS and DEM stimulation but decreased by H2O2 and NO stimulation. Also, the taurine efflux was regulated by TNF-α stimulation. In conclusion, the taurine transport through the blood-placental barrier was regulated in oxidative stress conditions, and these results demonstrated that oxidative stress affected the taurine supplies to fetus and taurine level of fetus. | - |
dc.format.extent | 8 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | 한국약제학회 | - |
dc.title | The Regulation of Taurine Transport through the Blood-Placental Barrier under Oxidative Stress | - |
dc.type | Article | - |
dc.publisher.location | 대한민국 | - |
dc.identifier.bibliographicCitation | 약제학회지, v.38, no.5, pp 295 - 302 | - |
dc.citation.title | 약제학회지 | - |
dc.citation.volume | 38 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 295 | - |
dc.citation.endPage | 302 | - |
dc.identifier.kciid | ART001286660 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | kci | - |
dc.subject.keywordAuthor | Blood-placental barrier | - |
dc.subject.keywordAuthor | TR-TBT | - |
dc.subject.keywordAuthor | Taurine transporter | - |
dc.subject.keywordAuthor | Oxidative stress | - |
dc.subject.keywordAuthor | Calcium ion | - |
dc.identifier.url | http://kiss.kstudy.com/thesis/thesis-view.asp?key=2730463 | - |
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