Antioxidant and Anti-Inflammatory Effects of 3-Dehydroxyceanothetric Acid 2-Methyl Ester Isolated from Ziziphus jujuba Mill. against Cisplatin-Induced Kidney Epithelial Cell Death
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Dahae | - |
dc.contributor.author | Kang, Kyo Bin | - |
dc.contributor.author | Hwang, Gwi Seo | - |
dc.contributor.author | Choi, You-Kyoung | - |
dc.contributor.author | Kim, Tae Kon | - |
dc.contributor.author | Kang, Ki Sung | - |
dc.date.accessioned | 2022-04-19T08:48:52Z | - |
dc.date.available | 2022-04-19T08:48:52Z | - |
dc.date.issued | 2021-11 | - |
dc.identifier.issn | 2218-273X | - |
dc.identifier.issn | 2218-273X | - |
dc.identifier.uri | https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/146135 | - |
dc.description.abstract | Cisplatin is a platinum-based chemotherapeutic agent for treating solid tumors; however, it presents a risk factor for nephropathy. In the present study, we investigated the antioxidant and anti-inflammatory effects of 3-dehydroxyceanothetric acid 2-methyl ester (3DC2ME) isolated from Ziziphus jujuba Mill. in LLC-PK1 cells following cisplatin-induced cytotoxicity. These cells were exposed to 3DC2ME for 2 h, followed by treatment with cisplatin for 24 h. The treated cells were subjected to cell viability analysis using the Ez-Cytox assay. Reactive oxygen species (ROS) were detected via 2 & PRIME;, 7 & PRIME;- dichlorodihydrofluorescein diacetate (DCFH-DA) staining. In addition, western blotting and fluorescent immunostaining were performed to evaluate protein expressions related to oxidative stress and inflammation pathways. Pretreatment with 3DC2ME protected LLC-PK1 cells from cisplatin-induced cytotoxicity and oxidative stress. In addition, pretreatment with 3DC2ME upregulated heme oxygenase 1 (HO-1) via the nuclear factor erythroid 2-related factor 2 (Nrf2) pathway in the cisplatin-treated LLC-PK1 cells. Furthermore, the increase in the expressions of I kappa B kinase alpha/beta (IKK alpha/beta), inhibitor of kappa B alpha (I kappa B alpha), nuclear factor kappa B (NF-kappa B), inducible nitric oxide synthase (iNOS), and cyclooxygenase-2 (COX-2) in these cells was inhibited. These results provide basic scientific evidence for understanding the antioxidant and anti-inflammatory effects of 3DC2ME isolated from Z. jujuba against cisplatin-induced kidney epithelial cell death. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | MDPI | - |
dc.title | Antioxidant and Anti-Inflammatory Effects of 3-Dehydroxyceanothetric Acid 2-Methyl Ester Isolated from Ziziphus jujuba Mill. against Cisplatin-Induced Kidney Epithelial Cell Death | - |
dc.type | Article | - |
dc.publisher.location | 스위스 | - |
dc.identifier.doi | 10.3390/biom11111614 | - |
dc.identifier.scopusid | 2-s2.0-85118224289 | - |
dc.identifier.wosid | 000723880700001 | - |
dc.identifier.bibliographicCitation | BIOMOLECULES, v.11, no.11 | - |
dc.citation.title | BIOMOLECULES | - |
dc.citation.volume | 11 | - |
dc.citation.number | 11 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.subject.keywordPlus | NRF2/HO-1 SIGNALING PATHWAY | - |
dc.subject.keywordPlus | INDUCED NEPHROTOXICITY | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | MECHANISMS | - |
dc.subject.keywordAuthor | Ziziphus jujuba Mill | - |
dc.subject.keywordAuthor | LLC-PK1 | - |
dc.subject.keywordAuthor | nephrotoxicity | - |
dc.subject.keywordAuthor | oxidative stress | - |
dc.subject.keywordAuthor | inflammation | - |
dc.identifier.url | https://www.mdpi.com/2218-273X/11/11/1614 | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
Sookmyung Women's University. Cheongpa-ro 47-gil 100 (Cheongpa-dong 2ga), Yongsan-gu, Seoul, 04310, Korea02-710-9127
Copyright©Sookmyung Women's University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.