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Downregulation of peritoneal macrophage activity in mice exposed to bisphenol a during pregnancy and lactation

Authors
Pyo, Myoung YunKim, Hae JuBack, Seung KyungYang, Mihi
Issue Date
Nov-2007
Publisher
PHARMACEUTICAL SOC KOREA
Keywords
bisphenol A; dams; offspring; peritoneal macrophages; nitric oxide; tumor necrosis factor-alpha (TNF-alpha)
Citation
ARCHIVES OF PHARMACAL RESEARCH, v.30, no.11, pp.1476 - 1481
Journal Title
ARCHIVES OF PHARMACAL RESEARCH
Volume
30
Number
11
Start Page
1476
End Page
1481
URI
https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/14621
DOI
10.1007/BF02977374
ISSN
0253-6269
Abstract
Bisphenol A (BPA) is an environmental endocrine disrupter that is known to be transferred to the fetus via the placenta and to the neonate via milk. In this study, we investigated BPA-induced alterations of the activities of murine peritoneal macrophages in dams and 7 week old offspring of dams exposed to BPA from gestational day 7 until lactation on day 21 after delivery, i.e. 34-36 days. BPA was administered in drinking water at three doses, 15, 75, and 300 mg/L. Dams were sacrificed 21 days after delivery and offspring at the age of 7 weeks. Peritoneal macrophages were cultured in the presence of LPS or LPS plus IFN-gamma for 2 or 4 days. We found that nitric oxide (NO) production by maternal macrophages was significantly decreased in a BPA-dose dependent manner. However, while a significant reduction of NO production by macrophages in the offspring was observed at BPA concentrations of 75 mg/L and 300 mg/L in drinking water, this effect was not seen at the lowest concentration of 15 mg/L. Similar inhibition of tumor necrosis factor-a (TNF-alpha) production was observed with macrophages from both BPA-exposed dams and offspring. Thus, our results suggest that exposure to BPA during gestation and lactation induces downregulation of the activities of macrophages in both dams and offspring.
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