Involvement of HDAC1 and the PI3K/PKC signaling pathways in NF-kB activation by the HDAC inhibitor apicidin
DC Field | Value | Language |
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dc.contributor.author | Kim, Yong Kee | - |
dc.contributor.author | Dong-Wan Seo | - |
dc.contributor.author | Dong-Won Kang | - |
dc.contributor.author | Hoi Young Lee | - |
dc.contributor.author | Jeung-Whan Han | - |
dc.contributor.author | Su-Nam Kim | - |
dc.date.accessioned | 2022-04-19T08:57:13Z | - |
dc.date.available | 2022-04-19T08:57:13Z | - |
dc.date.issued | 2006-09 | - |
dc.identifier.issn | 0006-291X | - |
dc.identifier.issn | 1090-2104 | - |
dc.identifier.uri | https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/146265 | - |
dc.description.abstract | Histone deacetylase (HDAC) inhibitors are appreciated as one of promising anticancer drugs, but they exert differential responses depending on the cell type. We recently reported the critical role of NF-kappa B as a modulator in determining cell fate for apoptosis in response to an HDAC inhibitor. In this study, we investigate a possible signaling pathway required for NF-kappa B activation in response to the HDAC inhibitor apicidin. Treatment of HeLa cells with apicidin leads to an increase in transcriptional activity of NF-kappa B and the expression of its target genes, IL-8 and TNF-alpha. TNF-alpha expression by apicidin is induced at earlier time points than NF-kappa B activation or IL-8 expression. In addition, our data show that the early expression of TNF-alpha does not lead to activation of NF-kappa B, because disruption of TNF-alpha activity by a neutralizing antibody does not affect nuclear translocation of NF-kappa B, I kappa B alpha degradation or reporter gene activation by apicidin. However, this activation of NF-kappa B requires the PI3K and PKC signaling pathways, but not ERK or JNK. Furthermore, apicidin activation of NF-kappa B seems to result from HDAC1 inhibition, as evidenced by the observation that overexpression of HDAC1, but not HDAC2, 3 or 4, dramatically inhibits NF-kappa B reporter gene activity. Collectively, our results suggest that activation of NF-kappa B signaling by apicidin requires both the PI3K/PKC signaling pathways and HDAC1, and functions as a critical modulator in determining the cellular effect of apicidin. (c) 2006 Elsevier Inc. All rights reserved. | - |
dc.format.extent | 6 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Academic Press Inc. Elsevier Science | - |
dc.title | Involvement of HDAC1 and the PI3K/PKC signaling pathways in NF-kB activation by the HDAC inhibitor apicidin | - |
dc.type | Article | - |
dc.publisher.location | 미국 | - |
dc.identifier.doi | 10.1016/j.bbrc.2006.06.196 | - |
dc.identifier.scopusid | 2-s2.0-33746380872 | - |
dc.identifier.wosid | 000239681100034 | - |
dc.identifier.bibliographicCitation | Biochemical and Biophysical Research Communications, v.347, no.4, pp 1088 - 1093 | - |
dc.citation.title | Biochemical and Biophysical Research Communications | - |
dc.citation.volume | 347 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 1088 | - |
dc.citation.endPage | 1093 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S0006291X06015506?via%3Dihub | - |
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