Catalytic approach to in vivo metabolism of atractylenolide III using biomimetic iron-porphyrin complexes
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lim, Hanae | - |
dc.contributor.author | Jeon, Hyeri | - |
dc.contributor.author | Hong, Seungwoo | - |
dc.contributor.author | Kim, Jung-Hoon | - |
dc.date.accessioned | 2022-04-19T09:01:48Z | - |
dc.date.available | 2022-04-19T09:01:48Z | - |
dc.date.issued | 2021-10 | - |
dc.identifier.issn | 2046-2069 | - |
dc.identifier.issn | 2046-2069 | - |
dc.identifier.uri | https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/146308 | - |
dc.description.abstract | Atractylenolide III (AT-III) is a pharmacologically effective phytochemical and is known to be oxygenated during systemic metabolism mainly by cytochrome P450 enzymes (CYP450s), iron-containing porphyrin-based oxygenases. In rat plasma samples, the oxygenated metabolite of orally ingested AT-III was determined using liquid chromatography/mass spectrometry and the oxygenated form of AT-III was maintained at higher levels than the original form of AT-III. In situ catalytic reactions using the iron(iv)-oxo porphyrin pi-cation radical complex, [(tmp(+))Fe-IV(O)](+), demonstrated that both H-atom abstraction and an oxygen rebound mechanism participated in the oxygenation process of AT-III. Density functional theory (DFT) confirmed the oxidative transformation occurred at the 4th and 10th carbon positions of AT-III. Co-treatment with acetaminophen had different effects between in vivo and in situ models of AT-III metabolism. AT-III was metabolized via an oxygenation process in the rat body, where CYP450 and other O-2-activating metalloenzymes might participate in the metabolism. The present work provided the oxidative metabolism of AT-III using an in vivo model parallel with in situ biomimetic reaction models. | - |
dc.format.extent | 7 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | ROYAL SOC CHEMISTRY | - |
dc.title | Catalytic approach to in vivo metabolism of atractylenolide III using biomimetic iron-porphyrin complexes | - |
dc.type | Article | - |
dc.publisher.location | 영국 | - |
dc.identifier.doi | 10.1039/d1ra05014a | - |
dc.identifier.scopusid | 2-s2.0-85120440045 | - |
dc.identifier.wosid | 000704921600001 | - |
dc.identifier.bibliographicCitation | RSC ADVANCES, v.11, no.52, pp 33048 - 33054 | - |
dc.citation.title | RSC ADVANCES | - |
dc.citation.volume | 11 | - |
dc.citation.number | 52 | - |
dc.citation.startPage | 33048 | - |
dc.citation.endPage | 33054 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.subject.keywordPlus | MOLECULAR-ORBITAL METHODS | - |
dc.subject.keywordPlus | GAUSSIAN-BASIS SETS | - |
dc.subject.keywordPlus | DRUG-METABOLISM | - |
dc.subject.keywordPlus | 3RD-ROW ATOMS | - |
dc.subject.keywordPlus | EXTENSION | - |
dc.subject.keywordPlus | ENERGIES | - |
dc.subject.keywordPlus | ABSTRACTION | - |
dc.subject.keywordPlus | MECHANISMS | - |
dc.subject.keywordPlus | OXIDATION | - |
dc.subject.keywordPlus | PATHWAYS | - |
dc.identifier.url | https://pubs.rsc.org/en/content/articlelanding/2021/RA/D1RA05014A | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
Sookmyung Women's University. Cheongpa-ro 47-gil 100 (Cheongpa-dong 2ga), Yongsan-gu, Seoul, 04310, Korea02-710-9127
Copyright©Sookmyung Women's University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.