Structure-Activity Relationship of Phytoestrogen Analogs as ER alpha/beta Agonists with Neuroprotective Activities
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Cho, Hye Won | - |
dc.contributor.author | Gim, Hyo Jin | - |
dc.contributor.author | Li, Hua | - |
dc.contributor.author | Subedi, Lalita | - |
dc.contributor.author | Kim, Sun Yeou | - |
dc.contributor.author | Ryu, Jae-Ha | - |
dc.contributor.author | Jeon, Raok | - |
dc.date.accessioned | 2022-04-19T09:29:09Z | - |
dc.date.available | 2022-04-19T09:29:09Z | - |
dc.date.issued | 2021-01 | - |
dc.identifier.issn | 0009-2363 | - |
dc.identifier.issn | 1347-5223 | - |
dc.identifier.uri | https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/146838 | - |
dc.description.abstract | A set of isollavononid and llavonoid analogs was prepared and evaluated for estrogen receptor alpha (ER alpha) and ER beta transactivation and anti-neuroinflammatory activities. Structure activity relationship (SAR) study of naturally occurring phytoestrogens, their metabolites, and related isollavone analogs revealed the importance of the C-ring of isoflavonoids for ER activity and selectivity. Docking study suggested putative binding modes of daidzein 2 and dehydroequol 8 in the active site of ER alpha and ER beta, and provided an understanding of the promising activity and selectivity of dehydroequol 8. Among the tested compounds, equol 7 and dehydroequol 8 were the most potent ER alpha/beta agonists with ER beta selectivity and neuroprotective activity. This study provides knowledge on the SAR of isollavonoids for further development of potent and selective ER agonists with neuroprotective potential. | - |
dc.format.extent | 7 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | PHARMACEUTICAL SOC JAPAN | - |
dc.title | Structure-Activity Relationship of Phytoestrogen Analogs as ER alpha/beta Agonists with Neuroprotective Activities | - |
dc.type | Article | - |
dc.publisher.location | 일본 | - |
dc.identifier.doi | 10.1248/cpb.c20-00706 | - |
dc.identifier.scopusid | 2-s2.0-85098658648 | - |
dc.identifier.wosid | 000604910700016 | - |
dc.identifier.bibliographicCitation | CHEMICAL & PHARMACEUTICAL BULLETIN, v.69, no.1, pp 99 - 105 | - |
dc.citation.title | CHEMICAL & PHARMACEUTICAL BULLETIN | - |
dc.citation.volume | 69 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 99 | - |
dc.citation.endPage | 105 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.subject.keywordPlus | RECEPTOR | - |
dc.subject.keywordPlus | BETA | - |
dc.subject.keywordAuthor | phytoestrogen | - |
dc.subject.keywordAuthor | estrogen receptor agonist | - |
dc.subject.keywordAuthor | structure activity relationship | - |
dc.subject.keywordAuthor | anti-neuroinflmmation | - |
dc.identifier.url | https://www.jstage.jst.go.jp/article/cpb/69/1/69_c20-00706/_article | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
Sookmyung Women's University. Cheongpa-ro 47-gil 100 (Cheongpa-dong 2ga), Yongsan-gu, Seoul, 04310, Korea02-710-9127
Copyright©Sookmyung Women's University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.