Inactivation of Mxi1 induces IL-8 secretion activation in polycystic kidney
DC Field | Value | Language |
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dc.contributor.author | Yoo, Kyung Hyun | - |
dc.contributor.author | Sung, Young Hoon | - |
dc.contributor.author | Yang, Moon Hee | - |
dc.contributor.author | Jeon, Jeong Ok | - |
dc.contributor.author | Yook, Yeon Joo | - |
dc.contributor.author | Woo, Yu Mi | - |
dc.contributor.author | Lee, Han-Woong | - |
dc.contributor.author | Park, Jong Hoon | - |
dc.date.available | 2021-02-22T15:02:49Z | - |
dc.date.issued | 2007-04 | - |
dc.identifier.issn | 0006-291X | - |
dc.identifier.issn | 1090-2104 | - |
dc.identifier.uri | https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/14701 | - |
dc.description.abstract | The Mxil proteins are biochemical and biological antagonists of c-myc oncoprotein. It has been reported that the overexpression pattern of c-myc might be similar to a molecular feature of early and late stages of human autosomal dominant polycystic kidney disease. We identified the cyst phenotype in Mxil-deficient mice aged 6-12 months using H&E staining. Some chemokines containing a protein domain similar to human IL-8, which is associated with the inflammatory response, were subsequently selected from the up-regulated genes. We confirmed the expression level of these chemokines and measured protein concentrations of IL-8 using ELISA in the Mxil-knockdown cells. IL-8 was found to be significantly increased in Mxil-knockdown cells. We found that p38 MAP kinase activation was involved in the signal transduction of the Mxil-inactivated secretion of IL-8. Therefore, we could suggest that the inactivation of Mxil leads to the inflammatory response and has the potential to induce polycystic renal disease. (c) 2007 Elsevier Inc. All rights reserved. | - |
dc.format.extent | 6 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | ACADEMIC PRESS INC ELSEVIER SCIENCE | - |
dc.title | Inactivation of Mxi1 induces IL-8 secretion activation in polycystic kidney | - |
dc.type | Article | - |
dc.publisher.location | 미국 | - |
dc.identifier.doi | 10.1016/j.bbrc.2007.02.103 | - |
dc.identifier.scopusid | 2-s2.0-33947190405 | - |
dc.identifier.wosid | 000245419300014 | - |
dc.identifier.bibliographicCitation | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.356, no.1, pp 85 - 90 | - |
dc.citation.title | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.citation.volume | 356 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 85 | - |
dc.citation.endPage | 90 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Biophysics | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biophysics | - |
dc.subject.keywordPlus | DISEASE | - |
dc.subject.keywordPlus | GENE | - |
dc.subject.keywordPlus | PROTEIN | - |
dc.subject.keywordPlus | ENCODES | - |
dc.subject.keywordAuthor | Mxi1 | - |
dc.subject.keywordAuthor | IL-8 | - |
dc.subject.keywordAuthor | polycystic kidney | - |
dc.subject.keywordAuthor | inflammatory response | - |
dc.subject.keywordAuthor | p38 | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/abs/pii/S0006291X07003774?via%3Dihub | - |
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