Angiogenesis and vasculogenic mimicry as therapeutic targets in ovarian cancer
DC Field | Value | Language |
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dc.contributor.author | Lim, Dansaem | - |
dc.contributor.author | Do, Yeojin | - |
dc.contributor.author | Kwon, Byung Su | - |
dc.contributor.author | Chang, Woochul | - |
dc.contributor.author | Lee, Myeong-Sok | - |
dc.contributor.author | Kim, Jongmin | - |
dc.contributor.author | Cho, Jin Gu | - |
dc.date.available | 2021-02-22T05:24:32Z | - |
dc.date.issued | 2020-06 | - |
dc.identifier.issn | 1976-6696 | - |
dc.identifier.issn | 1976-670X | - |
dc.identifier.uri | https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/1472 | - |
dc.description.abstract | Tumor angiogenesis is an essential process for growth and metastasis of cancer cells as it supplies tumors with oxygen and nutrients. During tumor angiogenesis, many pro-angiogenic factors are secreted by tumor cells to induce their own vascularization via activation of pre-existing host endothelium. However, accumulating evidence suggests that vasculogenic mimicry (VM) is a key alternative mechanism for tumor vascularization when tumors are faced with insufficient supply of oxygen and nutrients. VM is a tumor vascularization mechanism in which tumors create a blood supply system, in contrast to tumor angiogenesis mechanisms that depend on pre-existing host endothelium. VM is closely associated with tumor progression and poor prognosis in many cancels. Therefore, inhibition of VM may be a promising therapeutic strategy and may overcome the limitations of anti-angiogenesis therapy for cancer patients. In this review, we provide an overview of the current anti-angiogenic therapies for ovarian cancer and the current state of knowledge regarding the links between microRNAs and the VM process, with a focus on the mechanism that regulates associated signaling pathways in ovarian cancer. Moreover, we discuss the potential for VM as a therapeutic strategy against ovarian cancer. | - |
dc.format.extent | 8 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | KOREAN SOCIETY BIOCHEMISTRY & MOLECULAR BIOLOGY | - |
dc.title | Angiogenesis and vasculogenic mimicry as therapeutic targets in ovarian cancer | - |
dc.type | Article | - |
dc.publisher.location | 대한민국 | - |
dc.identifier.doi | 10.5483/BMBRep.2020.53.6.060 | - |
dc.identifier.scopusid | 2-s2.0-85087111009 | - |
dc.identifier.wosid | 000545933200001 | - |
dc.identifier.bibliographicCitation | BMB REPORTS, v.53, no.6, pp 291 - 298 | - |
dc.citation.title | BMB REPORTS | - |
dc.citation.volume | 53 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 291 | - |
dc.citation.endPage | 298 | - |
dc.type.docType | Review | - |
dc.identifier.kciid | ART002598592 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.subject.keywordPlus | ENDOTHELIAL-GROWTH-FACTOR | - |
dc.subject.keywordPlus | EPITHELIAL-MESENCHYMAL TRANSITION | - |
dc.subject.keywordPlus | HUMAN-MELANOMA CELLS | - |
dc.subject.keywordPlus | DOUBLE-BLIND | - |
dc.subject.keywordPlus | FUNCTIONAL-SIGNIFICANCE | - |
dc.subject.keywordPlus | CLINICAL-SIGNIFICANCE | - |
dc.subject.keywordPlus | MOLECULAR-MECHANISMS | - |
dc.subject.keywordPlus | CHANNEL FORMATION | - |
dc.subject.keywordPlus | TUMOR-GROWTH | - |
dc.subject.keywordPlus | VE-CADHERIN | - |
dc.subject.keywordAuthor | Angiogenesis | - |
dc.subject.keywordAuthor | Ovarian cancer | - |
dc.subject.keywordAuthor | Therapeutic target | - |
dc.subject.keywordAuthor | Tumor vascularization | - |
dc.subject.keywordAuthor | Vasculogenic mimicry | - |
dc.identifier.url | http://www.bmbreports.org/journal/view.html?doi=10.5483/BMBRep.2020.53.6.060 | - |
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