An endothelial apelin-FGF link mediated by miR-424 and miR-503 is disrupted in pulmonary arterial hypertension
DC Field | Value | Language |
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dc.contributor.author | Kim, Jongmin | - |
dc.contributor.author | Kang, Yujung | - |
dc.contributor.author | Kojima, Yoko | - |
dc.contributor.author | Lighthouse, Janet K | - |
dc.contributor.author | Hu, Xiaoyue | - |
dc.contributor.author | Aldred, Micheala A | - |
dc.contributor.author | McLean, Danielle L | - |
dc.contributor.author | Park, Hyekyung | - |
dc.contributor.author | Comhair, Suzy A | - |
dc.contributor.author | Greif, Daniel M | - |
dc.contributor.author | Erzurum, Serpil C | - |
dc.contributor.author | Chun, Hyung J | - |
dc.date.accessioned | 2022-04-19T10:11:32Z | - |
dc.date.available | 2022-04-19T10:11:32Z | - |
dc.date.issued | 2013-01 | - |
dc.identifier.issn | 1078-8956 | - |
dc.identifier.issn | 1546-170X | - |
dc.identifier.uri | https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/147505 | - |
dc.description.abstract | Pulmonary arterial hypertension (PAH) is characterized by vascular remodeling associated with obliteration of pulmonary arterioles and formation of plexiform lesions composed of hyperproliferative endothelial and vascular smooth-muscle cells. Here we describe a microRNA (miRNA)-dependent association between apelin (APLN) and fibroblast growth factor 2 (FGF2) signaling in pulmonary artery endothelial cells (PAECs). APLN deficiency in these cells led to increased expression of FGF2 and its receptor FGFR1 as a consequence of decreased expression of miR-424 and miR-503, which directly target FGF2 and FGFR1. miR-424 and miR-503 were downregulated in PAH, exerted antiproliferative effects in PAECs and inhibited the capacity of PAEC-conditioned medium to induce the proliferation of pulmonary artery smooth-muscle cells. Reconstitution of miR-424 and miR-503 in vivo ameliorated pulmonary hypertension in experimental models. These studies identify an APLN-dependent miRNA-FGF signaling axis needed for the maintenance of pulmonary vascular homeostasis. | - |
dc.format.extent | 9 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.title | An endothelial apelin-FGF link mediated by miR-424 and miR-503 is disrupted in pulmonary arterial hypertension | - |
dc.type | Article | - |
dc.publisher.location | 미국 | - |
dc.identifier.doi | 10.1038/nm.3040 | - |
dc.identifier.scopusid | 2-s2.0-84872078405 | - |
dc.identifier.wosid | 000313230300028 | - |
dc.identifier.bibliographicCitation | NATURE MEDICINE, v.19, no.1, pp 74 - 82 | - |
dc.citation.title | NATURE MEDICINE | - |
dc.citation.volume | 19 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 74 | - |
dc.citation.endPage | 82 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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