Apelin/APJ Signaling Is a Critical Regulator of Statin Effects in Vascular Endothelial Cells-Brief Report
DC Field | Value | Language |
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dc.contributor.author | McLean, Danielle L. | - |
dc.contributor.author | Kim, Jongmin | - |
dc.contributor.author | Kang, Yujung | - |
dc.contributor.author | Shi, Hong | - |
dc.contributor.author | Atkins, G. Brandon | - |
dc.contributor.author | Jain, Mukesh K. | - |
dc.contributor.author | Chun, Hyung J. | - |
dc.date.accessioned | 2022-04-19T10:23:19Z | - |
dc.date.available | 2022-04-19T10:23:19Z | - |
dc.date.issued | 2012-11 | - |
dc.identifier.issn | 1079-5642 | - |
dc.identifier.issn | 1524-4636 | - |
dc.identifier.uri | https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/147558 | - |
dc.description.abstract | Objective-The endothelial response elicited by the G-protein-coupled receptor pathway involving apelin and APJ predicts an overall vasoprotective effect. As a number of downstream endothelial targets of apelin/APJ signaling are also known to be targeted by statins (3-hydroxy-3-methyl-glutaryl [HMG]-CoA reductase inhibitors) as potential mediators of their known pleiotropic effects, we evaluated for the involvement of apelin/APJ signaling in statin endothelial effects. Methods and Results-We found that disruption of apelin/APJ signaling in endothelial cells leads to significantly decreased expression of Kruppel-like factor 2, endothelial nitric oxide synthase, and thrombomodulin. We found that statin-mediated induction of Kruppel-like factor 2, endothelial nitric oxide synthase, and thrombomodulin expression, as well as inhibition of monocyte-endothelial adhesion, was abrogated by concurrent apelin knockdown. Moreover, we found that statins can transcriptionally regulate APJ in a Kruppel-like factor 2-dependent manner, demonstrating the presence of a positive-feedback loop. Conclusion-Our findings provide a novel mechanism by which the apelin/APJ pathway serves as a critical intermediary that links statin to its pleiotropic effects in regulating endothelial gene targets and function. (Arterioscler Thromb Va | - |
dc.format.extent | 1 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | LIPPINCOTT WILLIAMS WILKINS | - |
dc.title | Apelin/APJ Signaling Is a Critical Regulator of Statin Effects in Vascular Endothelial Cells-Brief Report | - |
dc.type | Article | - |
dc.publisher.location | 미국 | - |
dc.identifier.doi | 10.1161/ATVBAHA.112.300317 | - |
dc.identifier.scopusid | 2-s2.0-84871887199 | - |
dc.identifier.wosid | 000310058900017 | - |
dc.identifier.bibliographicCitation | ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, v.32, no.11, pp 2640 - 2640 | - |
dc.citation.title | ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY | - |
dc.citation.volume | 32 | - |
dc.citation.number | 11 | - |
dc.citation.startPage | 2640 | - |
dc.citation.endPage | 2640 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.identifier.url | https://www.ahajournals.org/doi/10.1161/ATVBAHA.112.300317?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed | - |
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