Inhibition of bone resorption in cultures of mouse calvariae by apicularen A
DC Field | Value | Language |
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dc.contributor.author | Hong, JangJa | - |
dc.contributor.author | Sasaki, Hirokazu | - |
dc.contributor.author | Niikura, Kazuaki | - |
dc.contributor.author | Yanai, Maiko | - |
dc.contributor.author | Nakano, Yasuhiro | - |
dc.contributor.author | Yokomakura, Aya | - |
dc.contributor.author | Ishihara, Kenji | - |
dc.contributor.author | Hirasawa, Noriyasu | - |
dc.contributor.author | Kang, Young-Sook | - |
dc.contributor.author | Oh, Joa Sub | - |
dc.contributor.author | Kwak, Jong Hwan | - |
dc.contributor.author | Zee, OkPyo | - |
dc.contributor.author | Ohuchi, Kazuo | - |
dc.date.available | 2021-02-22T15:03:33Z | - |
dc.date.issued | 2007-02 | - |
dc.identifier.issn | 0032-0943 | - |
dc.identifier.issn | 1439-0221 | - |
dc.identifier.uri | https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/14765 | - |
dc.description.abstract | Apicularens A and B were isolated from the myxobacterial genus Chondromyces apiculatus JW184. Apicularen A inhibited bafilomycin A1-sensitive ATP-dependent proton transport into microsome vesicles more potently than apicularen B. Bone resorption in cultures of mouse calvariae induced by human parathyroid hormone (PTH) or interleukin-1 beta (IL-1 beta) was inhibited by apicularen A at 10 and 100 nM, while apicularen B had no effect. The bisphosphonate incadronate inhibited bone resorption at 100 nM, being less effective than apicularen A. Our findings indicate that apicularen A inhibits bone resorption induced by PTH or IL-1 beta more potently than apicularen B, probably due to inhibition of the V-ATPase. | - |
dc.format.extent | 3 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | GEORG THIEME VERLAG KG | - |
dc.title | Inhibition of bone resorption in cultures of mouse calvariae by apicularen A | - |
dc.type | Article | - |
dc.publisher.location | 독일 | - |
dc.identifier.doi | 10.1055/s-2006-957069 | - |
dc.identifier.scopusid | 2-s2.0-34250350507 | - |
dc.identifier.wosid | 000244859600012 | - |
dc.identifier.bibliographicCitation | PLANTA MEDICA, v.73, no.2, pp 173 - 175 | - |
dc.citation.title | PLANTA MEDICA | - |
dc.citation.volume | 73 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 173 | - |
dc.citation.endPage | 175 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Plant Sciences | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalResearchArea | Integrative & Complementary Medicine | - |
dc.relation.journalWebOfScienceCategory | Plant Sciences | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
dc.relation.journalWebOfScienceCategory | Integrative & Complementary Medicine | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.subject.keywordPlus | RAW-264.7 CELLS | - |
dc.subject.keywordPlus | APOPTOSIS | - |
dc.subject.keywordPlus | INDUCTION | - |
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