Tyrosinase inhibitory constituents of Morus bombycis cortex
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 강교빈 | - |
dc.contributor.author | 김상두 | - |
dc.contributor.author | 김태범 | - |
dc.contributor.author | 정은주 | - |
dc.contributor.author | 김영중 | - |
dc.contributor.author | 성종혁 | - |
dc.contributor.author | 성상현 | - |
dc.date.accessioned | 2022-04-19T10:27:04Z | - |
dc.date.available | 2022-04-19T10:27:04Z | - |
dc.date.issued | 2011-09 | - |
dc.identifier.issn | 1226-3907 | - |
dc.identifier.uri | https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/147701 | - |
dc.description.abstract | Tyrosinase is one of the important enzymes in the mammalian melanin synthesis. In the process of melanin synthesis, tyrosine is oxidized to DOPA (3,4-dihydroxyphenylalanine), and DOPA is further oxidized to dopaquinone. Tyrosinase is an enzyme catalyzing this oxidation of tyrosine, so chemicals that inhibit the activity of tyrosinase can be used as skin whitening agents. In this study, we isolated five constituents from the 80% MeOH extract of Morus bombycis cortex by bioactivity-guided fractionation. We performed mushroom tyrosinase inhibition assay. As a result, 7,2′,4′-trihydroxyflavanone (1), 2′,4′,2,4,-tetrahydroxychalcone (2), and oxyresveratrol (3) showed the more potent inhibitory effect compared to kojic acid, a well-known skin whitening agent with antityrosinase effect. Moracinoside M (4) and moracin M-3′-O-β-D-glucopyranoside (5) also showed the moderate tyrosinase inhibitory activities. | - |
dc.format.extent | 4 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | 한국생약학회 | - |
dc.title | Tyrosinase inhibitory constituents of Morus bombycis cortex | - |
dc.type | Article | - |
dc.publisher.location | 대한민국 | - |
dc.identifier.scopusid | 2-s2.0-82255195810 | - |
dc.identifier.bibliographicCitation | Natural Product Sciences, v.17, no.3, pp 198 - 201 | - |
dc.citation.title | Natural Product Sciences | - |
dc.citation.volume | 17 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 198 | - |
dc.citation.endPage | 201 | - |
dc.identifier.kciid | ART001591947 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.identifier.url | https://kiss.kstudy.com/thesis/thesis-view.asp?key=2946248 | - |
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