Enhancement of ectopic bone formation by bone morphogenetic protein-2 delivery using heparin-conjugated PLGA nanoparticles with transplantation of bone marrow-derived mesenchymal stem cells
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim S.E. | - |
dc.contributor.author | Jeon O. | - |
dc.contributor.author | Lee J.B. | - |
dc.contributor.author | Bae M.S. | - |
dc.contributor.author | Chun H.-J. | - |
dc.contributor.author | Moon S.-H. | - |
dc.contributor.author | Kwon I.K. | - |
dc.date.accessioned | 2022-04-19T11:02:49Z | - |
dc.date.available | 2022-04-19T11:02:49Z | - |
dc.date.issued | 2008-11 | - |
dc.identifier.issn | 1021-7770 | - |
dc.identifier.issn | 1423-0127 | - |
dc.identifier.uri | https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/148156 | - |
dc.description.abstract | This study was performed to determine if a combination of previously undifferentiated bone marrow-derived mesenchymal stem cells (BMMSCs) and exogenous bone morphogenetic protein-2 (BMP-2) delivered via heparin-conjugated PLGA nanoparticles (HCPNs) would extensively regenerate bone in vivo. In vitro testing found that the HCPNs were able to release BMP-2 over a 2-week period. Human BMMSCs cultured in medium containing BMP-2-loaded HCPNs for 2 weeks differentiated toward osteogenic cells expressing alkaline phosphatase (ALP), osteopontin (OPN) and osteocalcin (OCN) mRNA, while cells without BMP-2 expressed only ALP. In vivo testing found that undifferentiated BMMSCs with BMP-2-loaded HCPNs induce far more extensive bone formation than either implantation of BMP-2-loaded HCPNs or osteogenically differentiated BMMSCs. This study demonstrates the feasibility of extensive in vivo bone regeneration by transplantation of undifferentiated BMMSCs and BMP-2 delivery via HCPNs. ?? 2008 National Science Council Taipei. | - |
dc.format.extent | 7 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | S. Karger AG | - |
dc.title | Enhancement of ectopic bone formation by bone morphogenetic protein-2 delivery using heparin-conjugated PLGA nanoparticles with transplantation of bone marrow-derived mesenchymal stem cells | - |
dc.type | Article | - |
dc.publisher.location | 네델란드 | - |
dc.identifier.doi | 10.1007/s11373-008-9277-4 | - |
dc.identifier.scopusid | 2-s2.0-56349132615 | - |
dc.identifier.wosid | 000260957100010 | - |
dc.identifier.bibliographicCitation | Journal of Biomedical Science, v.15, no.6, pp 771 - 777 | - |
dc.citation.title | Journal of Biomedical Science | - |
dc.citation.volume | 15 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 771 | - |
dc.citation.endPage | 777 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordAuthor | Bone marrow-derived mesenchymal stem cell | - |
dc.subject.keywordAuthor | Bone morphogenetic protein-2 | - |
dc.subject.keywordAuthor | Bone regeneration | - |
dc.subject.keywordAuthor | Heparin-conjugated PLGA nanoparticles | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
Sookmyung Women's University. Cheongpa-ro 47-gil 100 (Cheongpa-dong 2ga), Yongsan-gu, Seoul, 04310, Korea02-710-9127
Copyright©Sookmyung Women's University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.