The inhibitory effects of eckol and dieckol from Ecklonia stolonifera on the expression of matrix metalloproteinase-1 in human dermal fibroblasts.
DC Field | Value | Language |
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dc.contributor.author | Min-Jeong JOE | - |
dc.contributor.author | Su-Nam KIM | - |
dc.contributor.author | Hye-Young CHOI | - |
dc.contributor.author | Woon-Seob SHIN | - |
dc.contributor.author | Gab-Man PARK | - |
dc.contributor.author | Dong-Won KANG | - |
dc.contributor.author | Kim, Yong Kee | - |
dc.date.accessioned | 2022-04-19T11:25:12Z | - |
dc.date.available | 2022-04-19T11:25:12Z | - |
dc.date.issued | 2006-08 | - |
dc.identifier.issn | 0918-6158 | - |
dc.identifier.issn | 1347-5215 | - |
dc.identifier.uri | https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/148572 | - |
dc.description.abstract | In order to develop new anti-photoaging agents, we examined the inhibitory effects of 29 seaweed extracts on transcriptional activities of NF-kappa B and AP-1, and MMP-1 expression. The extracts from 3 species of Alariaceae, Eisenia bicyclis, Ecklonia cava and Ecklonia stolonifera, have showed strong inhibition of both NF-kappa B and AP-1 reporter activity, which were well correlated with their abilities to inhibit MMP-1 expression. In addition, MMP-1 expression was dramatically attenuated by treatment with eckol or dieckol which were purely isolated from E. stolonifera, indicating that these compounds are active principles to inhibit MMP-1 expression in human dermal fibroblasts. Taken together, our data demonstrate the inhibitory effect of eckol and dieckol from Ecklonia species on MMP-1 expression in human dermal fibroblasts and provide a possibility to develop as an agent for the prevention and treatment of skin aging. | - |
dc.format.extent | 5 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Pharmaceutical Society of Japan | - |
dc.title | The inhibitory effects of eckol and dieckol from Ecklonia stolonifera on the expression of matrix metalloproteinase-1 in human dermal fibroblasts. | - |
dc.type | Article | - |
dc.publisher.location | 일본 | - |
dc.identifier.doi | 10.1248/bpb.29.1735 | - |
dc.identifier.scopusid | 2-s2.0-33746773084 | - |
dc.identifier.wosid | 000240053500038 | - |
dc.identifier.bibliographicCitation | Biological and Pharmaceutical Bulletin, v.29, no.8, pp 1735 - 1739 | - |
dc.citation.title | Biological and Pharmaceutical Bulletin | - |
dc.citation.volume | 29 | - |
dc.citation.number | 8 | - |
dc.citation.startPage | 1735 | - |
dc.citation.endPage | 1739 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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