Enhancement of cell survival by stromal cell-derived factor-1/CXCL12 involves activation of CREB and induction of Mcl-1 and c-Fos in factor-dependent human cell line MO7e
DC Field | Value | Language |
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dc.contributor.author | Joo, EK | - |
dc.contributor.author | Broxmeyer, HE | - |
dc.contributor.author | Kwon, HJ | - |
dc.contributor.author | Kang, HB | - |
dc.contributor.author | Kim, JS | - |
dc.contributor.author | Lim, JS | - |
dc.contributor.author | Choe, YK | - |
dc.contributor.author | Choe, IS | - |
dc.contributor.author | Myung, PK | - |
dc.contributor.author | Lee, Y | - |
dc.date.accessioned | 2022-04-19T11:45:04Z | - |
dc.date.available | 2022-04-19T11:45:04Z | - |
dc.date.issued | 2004-10 | - |
dc.identifier.issn | 1547-3287 | - |
dc.identifier.issn | 1557-8534 | - |
dc.identifier.uri | https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/148890 | - |
dc.description.abstract | Stromal cell-derived factor-1 (SDF-1/CXCL12) enhances the survival of hematopoietic stem and progenitor cells in synergy with other cytokines such as granulocyte-macrophage colony-stimulating factor (GM-CSF), steel factor, and thrombopoietin (TPO), and both the PI3K/Akt and MAPK pathways have been linked to this survival. To further evaluate intracellular signaling involved in SDF-1/CXCL12 survival effects, we investigated modulation of downstream signaling molecules. The synergistic survival enhancement of SDF-1/CXCL12 plus other cytokines were directly linked to enhanced phosphorylation of p70/85S6K and cAMP responsive element binding protein ( CREB), as well as enhanced induction of the Bcl-2 family member Mcl-1. Most prominently, c-Fos, a component of AP1 transcription factor, was synergistically induced by SDF-1/CXCL12 plus other cytokines. These results suggest that SDF-1/CXCL12 enhanced cell survival in synergy with other cytokines involves activation of CREB and induction of Mcl-1 and c-Fos. | - |
dc.format.extent | 8 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | MARY ANN LIEBERT INC | - |
dc.title | Enhancement of cell survival by stromal cell-derived factor-1/CXCL12 involves activation of CREB and induction of Mcl-1 and c-Fos in factor-dependent human cell line MO7e | - |
dc.type | Article | - |
dc.publisher.location | 미국 | - |
dc.identifier.doi | 10.1089/scd.2004.13.563 | - |
dc.identifier.scopusid | 2-s2.0-8144228678 | - |
dc.identifier.wosid | 000225000100014 | - |
dc.identifier.bibliographicCitation | STEM CELLS AND DEVELOPMENT, v.13, no.5, pp 563 - 570 | - |
dc.citation.title | STEM CELLS AND DEVELOPMENT | - |
dc.citation.volume | 13 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 563 | - |
dc.citation.endPage | 570 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.identifier.url | https://www.liebertpub.com/doi/10.1089/scd.2004.13.563?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed | - |
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